ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000017969 Ptgis 10090 - 2:167191805-167240604 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000018113 Ptgis-001 167202907-167240604 protein_coding
  ENSMUST00000088041 Ptgis-002 167191805-167240589 protein_coding
  ENSMUST00000136271 Ptgis-003 167206522-167208416 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000018113ENSMUST00000088041
Transcript ID C166 Tie2+ EC mES
ENSMUST00000018113 145.288±31.90 18.809±13.43 5.658±3.18
ENSMUST00000088041 54.093±6.57 0.198±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008I4 CIL_0008I4_0002 VISTA
CIL_0006IT CIL_0006IT_0003 CGP
CIL_0001RU CIL_0001RU_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001516 ISS prostaglandin biosynthetic process
GO:0004497 IEA monooxygenase activity
GO:0005506 IEA iron ion binding
GO:0005515 IEA protein binding
GO:0005615 ISS extracellular space
GO:0005634 ISS nucleus
GO:0005783 ISS endoplasmic reticulum
GO:0005789 IEA endoplasmic reticulum membrane
GO:0005901 ISS caveola
GO:0008116 ISS prostaglandin-I synthase activity
GO:0016021 IEA integral component of membrane
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 IBA heme binding
GO:0032088 ISS negative regulation of NF-kappaB transcription factor activity
GO:0035360 ISS positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0042981 IBA regulation of apoptotic process
GO:0045019 ISS negative regulation of nitric oxide biosynthetic process
GO:0045766 ISS positive regulation of angiogenesis
GO:0050728 ISS negative regulation of inflammatory response
GO:0055114 IEA oxidation-reduction process
GO:0071347 ISS cellular response to interleukin-1
GO:0071354 ISS cellular response to interleukin-6
GO:0071456 ISS cellular response to hypoxia
GO:0097190 IEA apoptotic signaling pathway
GO:1900119 ISS positive regulation of execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060094 ptgis protein_coding Danio_rerio
ENSG00000124212 PTGIS prostaglandin I2 (prostacyclin) synthase protein_coding Homo_sapiens

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