ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: prostaglandin I2 (prostacyclin) synthase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000244043 PTGIS-001 ENSG00000124212 9606 - 20:49503874-49568146 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHUVECENST00000244043
Transcript ID BECs HAoEC HUVEC
ENST00000244043 0.178±0.04 0.797±0.31 2.559±1.99

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001516 IDA prostaglandin biosynthetic process
GO:0004497 IEA monooxygenase activity
GO:0005506 IEA iron ion binding
GO:0005515 IPI protein binding
GO:0005615 ISS extracellular space
GO:0005634 IDA nucleus
GO:0005783 IDA endoplasmic reticulum
GO:0005789 TAS endoplasmic reticulum membrane
GO:0005901 IDA caveola
GO:0006690 TAS icosanoid metabolic process
GO:0006805 TAS xenobiotic metabolic process
GO:0008116 IDA prostaglandin-I synthase activity
GO:0016021 IEA integral component of membrane
GO:0016705 IEA oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0019369 TAS arachidonic acid metabolic process
GO:0019371 TAS cyclooxygenase pathway
GO:0020037 IDA:IEA heme binding
GO:0032088 IDA negative regulation of NF-kappaB transcription factor activity
GO:0035360 IDA positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0044281 TAS small molecule metabolic process
GO:0045019 IDA negative regulation of nitric oxide biosynthetic process
GO:0045766 IMP positive regulation of angiogenesis
GO:0050728 IDA negative regulation of inflammatory response
GO:0055114 IEA oxidation-reduction process
GO:0071347 IEP cellular response to interleukin-1
GO:0071354 IEP cellular response to interleukin-6
GO:0071456 IDA cellular response to hypoxia
GO:0097190 IDA apoptotic signaling pathway
GO:1900119 IDA positive regulation of execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000018113 Ptgis-001 protein_coding Mus_musculus 0 1474
ENSMUST00000088041 Ptgis-002 protein_coding Mus_musculus 0 1391
ENSMUST00000136271 Ptgis-003 retained_intron Mus_musculus 0 196
ENSMUST00000034431 Tmem170-201 protein_coding Mus_musculus 0.0000002 64

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