ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: interferon regulatory factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000125347 IRF1 9606 - 5:132481609-132490798 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000245414 IRF1-001 132481609-132490798 protein_coding
  ENST00000405885 IRF1-008 132483086-132490262 protein_coding
  ENST00000437654 IRF1-002 132485667-132490777 protein_coding
  ENST00000439555 IRF1-009 132486664-132490726 nonsense_mediated_decay
  ENST00000458069 IRF1-010 132486341-132490304 protein_coding
  ENST00000459982 IRF1-004 132486123-132490765 retained_intron
  ENST00000463784 IRF1-003 132486617-132490767 processed_transcript
  ENST00000472045 IRF1-006 132483085-132489032 retained_intron
  ENST00000476613 IRF1-007 132486962-132489645 protein_coding
  ENST00000493208 IRF1-005 132488671-132490754 retained_intron
  ENST00000613424 IRF1-201 132484051-132490655 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000245414ENST00000405885ENST00000437654ENST00000439555ENST00000472045ENST00000493208ENST00000613424
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000245414 3.558±0.00 0.872±0.32 N/A 4.979±0.00 1.191±0.48
ENST00000405885 10.985±2.29 5.103±2.53 15.839±0.00 13.880±0.00 4.233±2.62
ENST00000437654 N/A 2.476±0.30 N/A N/A 4.701±1.97
ENST00000439555 N/A N/A N/A N/A 4.687±0.00
ENST00000472045 N/A 0.304±0.04 1.048±0.00 N/A 0.636±0.26
ENST00000493208 N/A N/A N/A N/A 1.703±0.20
ENST00000613424 N/A 4.456±0.67 N/A N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00093D CIL_00093D_0001 VISTA
CIL_0007RF CIL_0007RF_0001 VISTA

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000790 IDA nuclear chromatin
GO:0000975 IEA regulatory region DNA binding
GO:0000978 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0002819 TAS regulation of adaptive immune response
GO:0003677 TAS DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IPI protein binding
GO:0005634 TAS nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 ISS cytoplasm
GO:0005829 TAS cytosol
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006366 TAS transcription from RNA polymerase II promoter
GO:0006915 IDA apoptotic process
GO:0007050 IDA cell cycle arrest
GO:0007596 TAS blood coagulation
GO:0008285 TAS negative regulation of cell proliferation
GO:0010468 IEA regulation of gene expression
GO:0019221 TAS cytokine-mediated signaling pathway
GO:0032481 ISS positive regulation of type I interferon production
GO:0032728 IMP positive regulation of interferon-beta production
GO:0034124 ISS regulation of MyD88-dependent toll-like receptor signaling pathway
GO:0035458 IDA cellular response to interferon-beta
GO:0043374 IEA CD8-positive, alpha-beta T cell differentiation
GO:0043565 IEA sequence-specific DNA binding
GO:0045084 IEA positive regulation of interleukin-12 biosynthetic process
GO:0045088 TAS regulation of innate immune response
GO:0045590 ISS negative regulation of regulatory T cell differentiation
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IMP positive regulation of transcription, DNA-templated
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0051607 IDA defense response to virus
GO:0051726 TAS regulation of cell cycle
GO:0060333 ISS interferon-gamma-mediated signaling pathway
GO:0060337 TAS type I interferon signaling pathway
GO:0071260 IEP cellular response to mechanical stimulus
GO:2000564 ISS regulation of CD8-positive, alpha-beta T cell proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000018899 Irf1 protein_coding Mus_musculus

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