ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: Rho guanine nucleotide exchange factor (GEF) 4
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000136002 ARHGEF4 9606 + 2:130836916-131047263 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000326016 ARHGEF4-001 130916651-131047253 protein_coding
  ENST00000355771 ARHGEF4-009 131011683-131046189 protein_coding
  ENST00000392953 ARHGEF4-201 130916651-131047263 protein_coding
  ENST00000409303 ARHGEF4-005 130930958-131046189 protein_coding
  ENST00000409359 ARHGEF4-003 130837455-130947230 protein_coding
  ENST00000428230 ARHGEF4-202 130916651-131047263 protein_coding
  ENST00000438985 ARHGEF4-004 130916965-131046708 protein_coding
  ENST00000439368 ARHGEF4-010 131034972-131041276 processed_transcript
  ENST00000490728 ARHGEF4-006 131039529-131047253 retained_intron
  ENST00000496764 ARHGEF4-007 131034928-131039670 processed_transcript
  ENST00000525092 ARHGEF4-014 131041511-131044534 retained_intron
  ENST00000525839 ARHGEF4-002 130917431-131047251 protein_coding
  ENST00000526381 ARHGEF4-008 130836916-130914485 processed_transcript
  ENST00000527365 ARHGEF4-013 131041313-131043670 retained_intron
  ENST00000528247 ARHGEF4-011 131035485-131040408 processed_transcript
  ENST00000532720 ARHGEF4-012 131041277-131045558 protein_coding
  ENST00000611048 ARHGEF4-203 130916651-131047263 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000326016ENST00000409303ENST00000409359ENST00000428230ENST00000490728ENST00000496764ENST00000525092ENST00000525839ENST00000527365ENST00000528247ENST00000532720
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000326016 N/A 0.263±0.07 N/A N/A
ENST00000409303 N/A N/A N/A 0.195±0.00
ENST00000409359 0.061±0.00 0.058±0.06 0.025±0.00 0.026±0.02
ENST00000428230 N/A 0.119±0.15 N/A 0.024±0.01
ENST00000490728 N/A 0.162±0.00 N/A 0.029±0.01
ENST00000496764 N/A N/A 0.239±0.00 0.054±0.01
ENST00000525092 N/A N/A N/A 0.094±0.00
ENST00000525839 0.029±0.00 0.113±0.07 N/A 0.029±0.02
ENST00000527365 N/A 0.086±0.00 N/A 0.111±0.03
ENST00000528247 N/A N/A N/A 0.126±0.00
ENST00000532720 N/A 0.448±0.00 N/A 0.127±0.13

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0001J9 CIL_0001J9_0001 CGP
CIL_0001J8 CIL_0001J8_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005085 IMP guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0007264 TAS small GTPase mediated signal transduction
GO:0019904 IPI protein domain specific binding
GO:0030032 IMP lamellipodium assembly
GO:0030676 IMP Rac guanyl-nucleotide exchange factor activity
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0032855 IMP positive regulation of Rac GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0042995 IEA cell projection
GO:0043065 TAS positive regulation of apoptotic process
GO:0043547 IMP positive regulation of GTPase activity
GO:0046847 IMP filopodium assembly
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000012914 arhgef4 protein_coding Danio_rerio
ENSMUSG00000037509 Arhgef4 protein_coding Mus_musculus

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