ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: Rho guanine nucleotide exchange factor (GEF) 4
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000525839 ARHGEF4-002 ENSG00000136002 9606 + 2:130917431-131047251 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHUVECENST00000525839
Transcript ID BECs HAoEC HUVEC
ENST00000525839 0.029±0.00 0.113±0.07 0.029±0.02

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0005085 IMP guanyl-nucleotide exchange factor activity
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005515 IPI:IEA protein binding
GO:0005829 TAS cytosol
GO:0005886 IEA plasma membrane
GO:0007264 TAS small GTPase mediated signal transduction
GO:0019904 IPI protein domain specific binding
GO:0030032 IMP lamellipodium assembly
GO:0030676 IMP Rac guanyl-nucleotide exchange factor activity
GO:0032855 IMP positive regulation of Rac GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0042995 IEA cell projection
GO:0043065 TAS positive regulation of apoptotic process
GO:0043547 IMP positive regulation of GTPase activity
GO:0046847 IMP filopodium assembly
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000159747 Arhgef4-004 protein_coding Mus_musculus 0 1925
ENSMUST00000047664 Arhgef4-001 protein_coding Mus_musculus 0 1685
ENSMUST00000162599 Arhgef4-005 protein_coding Mus_musculus 0 1088
ENSMUST00000162760 Arhgef4-002 retained_intron Mus_musculus 0 935
ENSMUST00000159021 Arhgef4-006 protein_coding Mus_musculus 0 835
ENSMUST00000160855 Arhgef4-003 nonsense_mediated_decay Mus_musculus 0 601
ENSMUST00000159059 Arhgef4-007 retained_intron Mus_musculus 0 601
ENSMUST00000022566 Spata13-201 protein_coding Mus_musculus 0 505
ENSMUST00000162945 Spata13-002 protein_coding Mus_musculus 0 505
ENSMUST00000160973 Spata13-001 protein_coding Mus_musculus 0 505
ENSMUST00000162131 Spata13-009 protein_coding Mus_musculus 0 211

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