ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: phosphodiesterase 5A, cGMP-specific
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000138735 PDE5A 9606 - 4:119494395-119628991 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264805 PDE5A-002 119498541-119627633 protein_coding
  ENST00000354960 PDE5A-001 119494395-119628991 protein_coding
  ENST00000394439 PDE5A-201 119494397-119628084 protein_coding
  ENST00000420633 PDE5A-003 119596526-119628065 protein_coding
  ENST00000502912 PDE5A-004 119538781-119542002 processed_transcript
  ENST00000503412 PDE5A-005 119500823-119519099 protein_coding
  ENST00000508914 PDE5A-007 119552441-119562972 retained_intron
  ENST00000509612 PDE5A-009 119507653-119519642 retained_intron
  ENST00000512450 PDE5A-012 119519079-119527276 processed_transcript
  ENST00000512494 PDE5A-006 119502390-119505935 retained_intron
  ENST00000512739 PDE5A-008 119521000-119543297 processed_transcript
  ENST00000513594 PDE5A-011 119517060-119539098 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000264805ENST00000354960ENST00000394439
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000264805 N/A N/A N/A 0.550±0.16
ENST00000354960 0.164±0.00 0.587±0.33 1.035±0.00 0.488±0.29
ENST00000394439 N/A 0.519±0.21 1.066±0.00 0.307±0.14

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0006YP CIL_0006YP_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004112 IEA cyclic-nucleotide phosphodiesterase activity
GO:0004114 NAS:IEA 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005515 IEA protein binding
GO:0005575 ND cellular_component
GO:0005829 TAS cytosol
GO:0007165 IEA signal transduction
GO:0007596 TAS blood coagulation
GO:0010613 IEA positive regulation of cardiac muscle hypertrophy
GO:0030553 TAS cGMP binding
GO:0030823 IEA regulation of cGMP metabolic process
GO:0042130 IEA negative regulation of T cell proliferation
GO:0043406 IEA positive regulation of MAP kinase activity
GO:0046068 IEA cGMP metabolic process
GO:0046069 IEA cGMP catabolic process
GO:0046872 IEA metal ion binding
GO:0047555 IEA 3',5'-cyclic-GMP phosphodiesterase activity
GO:0055118 IEA negative regulation of cardiac muscle contraction
GO:0055119 IEA relaxation of cardiac muscle
GO:0060282 IEA positive regulation of oocyte development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000051915 pde5ab protein_coding Danio_rerio
ENSDARG00000056806 PDE5A (2 of 2) protein_coding Danio_rerio
ENSMUSG00000053965 Pde5a protein_coding Mus_musculus

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