ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000053965 Pde5a 10090 + 3:122728947-122859374 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000066728 Pde5a-001 122728947-122859374 protein_coding
  ENSMUST00000198314 Pde5a-003 122730222-122776425 retained_intron
  ENSMUST00000199253 Pde5a-004 122795234-122807126 processed_transcript
  ENSMUST00000200389 Pde5a-002 122729570-122859372 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000066728ENSMUST00000198314ENSMUST00000200389
Transcript ID C166 Tie2+ EC mES
ENSMUST00000066728 1.273±0.30 2.423±1.48 1.690±0.27
ENSMUST00000198314 N/A 1.483±0.00 N/A
ENSMUST00000200389 0.867±0.40 2.966±0.34 1.284±0.48

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004112 IDA cyclic-nucleotide phosphodiesterase activity
GO:0004114 IMP 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0007165 IEA signal transduction
GO:0010613 IMP positive regulation of cardiac muscle hypertrophy
GO:0030553 IDA cGMP binding
GO:0030823 IGI regulation of cGMP metabolic process
GO:0042130 IMP negative regulation of T cell proliferation
GO:0043406 IMP positive regulation of MAP kinase activity
GO:0045745 IC positive regulation of G-protein coupled receptor protein signaling pathway
GO:0046068 IMP cGMP metabolic process
GO:0046069 IEA cGMP catabolic process
GO:0046872 IEA metal ion binding
GO:0047555 IEA 3',5'-cyclic-GMP phosphodiesterase activity
GO:0055118 IMP negative regulation of cardiac muscle contraction
GO:0055119 IMP relaxation of cardiac muscle
GO:0060282 IGI positive regulation of oocyte development

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000051915 pde5ab protein_coding Danio_rerio
ENSDARG00000056806 PDE5A (2 of 2) protein_coding Danio_rerio
ENSG00000138735 PDE5A phosphodiesterase 5A, cGMP-specific protein_coding Homo_sapiens

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