ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: ADAM metallopeptidase domain 15
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000143537 ADAM15 9606 + 1:155050566-155062775 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000271836 ADAM15-001 155051306-155062775 protein_coding
  ENST00000355956 ADAM15-037 155051286-155062758 protein_coding
  ENST00000356955 ADAM15-019 155051286-155062758 protein_coding
  ENST00000359280 ADAM15-023 155051286-155062758 protein_coding
  ENST00000360674 ADAM15-024 155051286-155062758 protein_coding
  ENST00000368412 ADAM15-025 155051286-155062758 protein_coding
  ENST00000368413 ADAM15-002 155051316-155062769 protein_coding
  ENST00000447332 ADAM15-027 155051352-155058683 protein_coding
  ENST00000449910 ADAM15-020 155051286-155062758 protein_coding
  ENST00000461234 ADAM15-011 155058246-155062704 processed_transcript
  ENST00000461564 ADAM15-005 155051308-155061758 retained_intron
  ENST00000462116 ADAM15-012 155058753-155061446 processed_transcript
  ENST00000464824 ADAM15-035 155062161-155062775 retained_intron
  ENST00000468053 ADAM15-013 155060266-155061332 processed_transcript
  ENST00000470779 ADAM15-009 155055802-155056261 processed_transcript
  ENST00000472434 ADAM15-003 155051354-155062768 processed_transcript
  ENST00000473905 ADAM15-007 155050566-155056238 processed_transcript
  ENST00000474709 ADAM15-016 155058710-155062775 processed_transcript
  ENST00000477533 ADAM15-004 155051304-155053988 processed_transcript
  ENST00000480331 ADAM15-006 155050727-155056146 processed_transcript
  ENST00000485346 ADAM15-029 155051316-155053978 processed_transcript
  ENST00000487956 ADAM15-008 155051326-155057100 processed_transcript
  ENST00000498481 ADAM15-036 155058239-155062747 retained_intron
  ENST00000525020 ADAM15-033 155056096-155057227 retained_intron
  ENST00000526491 ADAM15-021 155051286-155062758 nonsense_mediated_decay
  ENST00000527418 ADAM15-017 155050946-155062775 retained_intron
  ENST00000529473 ADAM15-022 155051286-155062758 nonsense_mediated_decay
  ENST00000531455 ADAM15-026 155051351-155062669 protein_coding
  ENST00000531703 ADAM15-030 155051303-155054148 processed_transcript
  ENST00000531831 ADAM15-031 155051351-155054323 processed_transcript
  ENST00000533732 ADAM15-028 155050681-155053992 processed_transcript
  ENST00000534019 ADAM15-032 155055409-155056407 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000271836ENST00000360674ENST00000368413ENST00000461234ENST00000461564ENST00000464824ENST00000474709ENST00000487956ENST00000526491ENST00000531455
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000271836 N/A 124.511±46.57 N/A 86.598±0.00 90.251±84.86
ENST00000360674 N/A 11.351±1.28 N/A N/A 95.921±50.05
ENST00000368413 172.772±49.29 55.922±11.78 N/A N/A N/A
ENST00000461234 249.764±0.00 N/A N/A N/A N/A
ENST00000461564 N/A N/A 14.833±0.00 N/A 5.485±6.20
ENST00000464824 988.927±551.42 N/A 382.621±0.00 N/A N/A
ENST00000474709 318.491±114.36 N/A N/A N/A 450.645±0.00
ENST00000487956 N/A 62.323±9.62 N/A N/A N/A
ENST00000526491 N/A N/A 15.170±0.00 N/A N/A
ENST00000531455 68.177±0.00 35.534±6.68 N/A 34.018±0.00 26.455±14.96

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001525 IEA angiogenesis
GO:0001953 IMP negative regulation of cell-matrix adhesion
GO:0004222 IEA metalloendopeptidase activity
GO:0005178 IMP integrin binding
GO:0005515 IPI:IEA protein binding
GO:0005886 TAS plasma membrane
GO:0006508 IEA proteolysis
GO:0007160 TAS cell-matrix adhesion
GO:0007229 IMP integrin-mediated signaling pathway
GO:0008237 IDA metallopeptidase activity
GO:0008270 IEA zinc ion binding
GO:0009986 IDA cell surface
GO:0016021 IEA integral component of membrane
GO:0017124 IPI SH3 domain binding
GO:0022617 TAS extracellular matrix disassembly
GO:0030054 IEA cell junction
GO:0030198 TAS extracellular matrix organization
GO:0030308 IMP negative regulation of cell growth
GO:0030336 IMP negative regulation of cell migration
GO:0030574 IEA collagen catabolic process
GO:0031410 IEA cytoplasmic vesicle
GO:0042246 IEA tissue regeneration
GO:0042995 IEA cell projection
GO:0045087 IDA innate immune response
GO:0060317 IEA cardiac epithelial to mesenchymal transition
GO:0070062 IDA extracellular vesicular exosome
GO:0070528 IDA protein kinase C signaling
GO:1900121 IMP negative regulation of receptor binding

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000089213 adam15 protein_coding Danio_rerio
ENSMUSG00000028041 Adam15 protein_coding Mus_musculus

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