ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: ankyrin 2, neuronal
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000145362 ANK2 9606 + 4:112818109-113383740 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264366 ANK2-026 113049729-113381471 protein_coding
  ENST00000357077 ANK2-001 113049676-113383740 protein_coding
  ENST00000394537 ANK2-002 113049676-113382112 protein_coding
  ENST00000502701 ANK2-025 113293360-113318606 retained_intron
  ENST00000503271 ANK2-009 112818109-113335871 protein_coding
  ENST00000503423 ANK2-010 112818109-113353713 protein_coding
  ENST00000504415 ANK2-022 113341712-113363440 protein_coding
  ENST00000504454 ANK2-005 113049650-113353764 protein_coding
  ENST00000504887 ANK2-018 113336344-113341818 processed_transcript
  ENST00000505342 ANK2-011 113357589-113383740 protein_coding
  ENST00000506344 ANK2-023 113373317-113381943 protein_coding
  ENST00000506722 ANK2-004 112818109-113383735 protein_coding
  ENST00000508007 ANK2-019 113347796-113365136 retained_intron
  ENST00000508613 ANK2-013 113116993-113236990 protein_coding
  ENST00000509550 ANK2-006 113292982-113381647 protein_coding
  ENST00000510275 ANK2-008 113341833-113381567 protein_coding
  ENST00000511380 ANK2-014 113145632-113196466 protein_coding
  ENST00000512298 ANK2-020 113348258-113350811 retained_intron
  ENST00000512999 ANK2-021 113141249-113151208 processed_transcript
  ENST00000514160 ANK2-017 113332982-113336593 retained_intron
  ENST00000514167 ANK2-024 113373359-113381516 protein_coding
  ENST00000514246 ANK2-012 113049656-113070150 processed_transcript
  ENST00000514960 ANK2-007 113318585-113383732 protein_coding
  ENST00000515034 ANK2-015 113174018-113237105 protein_coding
  ENST00000515644 ANK2-016 113317452-113330363 retained_intron
  ENST00000612754 ANK2-201 113355717-113383729 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000264366ENST00000357077ENST00000394537ENST00000502701ENST00000503271ENST00000503423ENST00000504454ENST00000504887ENST00000505342ENST00000506344ENST00000506722ENST00000508007ENST00000509550ENST00000510275ENST00000514160ENST00000514960ENST00000515034ENST00000612754
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000264366 N/A 0.044±0.03 N/A 0.003±0.00
ENST00000357077 N/A 0.067±0.00 N/A 0.003±0.00
ENST00000394537 N/A 0.088±0.00 N/A N/A
ENST00000502701 N/A N/A N/A 0.586±0.00
ENST00000503271 N/A N/A N/A 0.022±0.02
ENST00000503423 N/A N/A N/A 0.016±0.00
ENST00000504454 N/A N/A N/A 0.010±0.00
ENST00000504887 N/A 0.123±0.00 N/A N/A
ENST00000505342 N/A 0.108±0.02 N/A 0.016±0.00
ENST00000506344 N/A 0.403±0.00 N/A 0.101±0.07
ENST00000506722 0.014±0.00 N/A N/A 0.011±0.00
ENST00000508007 N/A N/A N/A 0.023±0.00
ENST00000509550 N/A 0.104±0.00 N/A N/A
ENST00000510275 N/A 0.027±0.00 N/A 0.057±0.04
ENST00000514160 N/A 0.101±0.00 N/A N/A
ENST00000514960 0.120±0.07 0.072±0.06 0.561±0.00 0.018±0.02
ENST00000515034 N/A N/A N/A 0.075±0.00
ENST00000612754 0.048±0.00 0.143±0.05 N/A N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0008WR CIL_0008WR_0001 VISTA
CIL_0006YO CIL_0006YO_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002027 IMP regulation of heart rate
GO:0003283 IMP atrial septum development
GO:0005200 IEA structural constituent of cytoskeleton
GO:0005515 IEA protein binding
GO:0005622 IGI intracellular
GO:0005737 IEA cytoplasm
GO:0005829 TAS cytosol
GO:0005856 IEA cytoskeleton
GO:0005886 ISS plasma membrane
GO:0005887 IEA integral component of plasma membrane
GO:0006874 ISS cellular calcium ion homeostasis
GO:0007165 IEA signal transduction
GO:0007399 IEA nervous system development
GO:0007411 TAS axon guidance
GO:0008104 IEA protein localization
GO:0010628 IGI positive regulation of gene expression
GO:0010881 IGI regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882 IMP regulation of cardiac muscle contraction by calcium ion signaling
GO:0014704 ISS intercalated disc
GO:0015459 IEA potassium channel regulator activity
GO:0016323 IDA basolateral plasma membrane
GO:0019899 IPI enzyme binding
GO:0019901 IPI protein kinase binding
GO:0030018 ISS Z disc
GO:0030315 ISS T-tubule
GO:0030507 IPI spectrin binding
GO:0030674 ISS protein binding, bridging
GO:0030913 IEA paranodal junction assembly
GO:0031430 ISS M band
GO:0031647 IC regulation of protein stability
GO:0031672 ISS A band
GO:0033292 ISS T-tubule organization
GO:0033365 IGI protein localization to organelle
GO:0034394 ISS protein localization to cell surface
GO:0034613 IGI cellular protein localization
GO:0036309 ISS protein localization to M-band
GO:0036371 ISS protein localization to T-tubule
GO:0042383 ISS sarcolemma
GO:0043005 IEA neuron projection
GO:0043034 ISS costamere
GO:0043268 ISS positive regulation of potassium ion transport
GO:0044325 ISS ion channel binding
GO:0045121 IEA membrane raft
GO:0045211 IEA postsynaptic membrane
GO:0048471 IEA perinuclear region of cytoplasm
GO:0050821 ISS protein stabilization
GO:0051117 ISS ATPase binding
GO:0051279 IGI regulation of release of sequestered calcium ion into cytosol
GO:0051597 IEA response to methylmercury
GO:0051924 IGI regulation of calcium ion transport
GO:0051928 ISS positive regulation of calcium ion transport
GO:0055117 IMP regulation of cardiac muscle contraction
GO:0060048 IEA cardiac muscle contraction
GO:0060307 IMP regulation of ventricular cardiac muscle cell membrane repolarization
GO:0070296 TAS sarcoplasmic reticulum calcium ion transport
GO:0070972 IGI protein localization to endoplasmic reticulum
GO:0072659 ISS protein localization to plasma membrane
GO:0072661 IEA protein targeting to plasma membrane
GO:0086004 IGI regulation of cardiac muscle cell contraction
GO:0086005 IMP ventricular cardiac muscle cell action potential
GO:0086014 IMP atrial cardiac muscle cell action potential
GO:0086015 ISS SA node cell action potential
GO:0086036 IEA regulation of cardiac muscle cell membrane potential
GO:0086046 TAS membrane depolarization during SA node cell action potential
GO:0086066 ISS atrial cardiac muscle cell to AV node cell communication
GO:0086070 IMP SA node cell to atrial cardiac muscle cell communication
GO:0086091 ISS regulation of heart rate by cardiac conduction
GO:1901018 ISS positive regulation of potassium ion transmembrane transporter activity
GO:1901019 ISS regulation of calcium ion transmembrane transporter activity
GO:1901021 ISS positive regulation of calcium ion transmembrane transporter activity
GO:2001257 IEA regulation of cation channel activity
GO:2001259 ISS positive regulation of cation channel activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009026 CR388002.1 protein_coding Danio_rerio
ENSDARG00000043313 ank2b protein_coding Danio_rerio
ENSMUSG00000032826 Ank2 protein_coding Mus_musculus

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