ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032826 Ank2 10090 - 3:126921612-127499350 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000044443 Ank2-001 126921612-126998462 protein_coding
  ENSMUST00000104965 Ank2-011 127496107-127499260 retained_intron
  ENSMUST00000182008 Ank2-003 127024774-127409031 protein_coding
  ENSMUST00000182025 Ank2-021 126940112-126955873 nonsense_mediated_decay
  ENSMUST00000182050 Ank2-010 127078119-127162238 retained_intron
  ENSMUST00000182062 Ank2-002 126937767-126956074 protein_coding
  ENSMUST00000182064 Ank2-024 126947112-127409059 protein_coding
  ENSMUST00000182078 Ank2-022 126921614-126943386 protein_coding
  ENSMUST00000182118 Ank2-014 126923912-126929812 protein_coding
  ENSMUST00000182212 Ank2-007 126925587-126928367 retained_intron
  ENSMUST00000182271 Ank2-008 126933196-126935117 retained_intron
  ENSMUST00000182316 Ank2-006 127336394-127499002 retained_intron
  ENSMUST00000182452 Ank2-026 127077514-127225933 protein_coding
  ENSMUST00000182547 Ank2-004 127024844-127409031 protein_coding
  ENSMUST00000182571 Ank2-023 126923913-126929812 protein_coding
  ENSMUST00000182588 Ank2-020 126921614-126923972 retained_intron
  ENSMUST00000182610 Ank2-016 127031173-127408967 protein_coding
  ENSMUST00000182711 Ank2-013 126959007-127499350 protein_coding
  ENSMUST00000182876 Ank2-012 127159714-127162204 retained_intron
  ENSMUST00000182959 Ank2-015 126959839-127408998 protein_coding
  ENSMUST00000182994 Ank2-009 127031173-127162346 protein_coding
  ENSMUST00000183075 Ank2-018 126950171-126998438 retained_intron
  ENSMUST00000183095 Ank2-017 127079945-127408954 protein_coding
  ENSMUST00000183097 Ank2-019 127015303-127024248 retained_intron
  ENSMUST00000183234 Ank2-005 127334794-127408995 retained_intron
  ENSMUST00000189368 Ank2-201 127498663-127499001 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; Tie2+ ECmESENSMUST00000044443ENSMUST00000182064ENSMUST00000182078ENSMUST00000182316ENSMUST00000182588
Transcript ID Tie2+ EC mES
ENSMUST00000044443 0.201±0.13 0.483±0.10
ENSMUST00000182064 0.441±0.00 0.294±0.04
ENSMUST00000182078 0.106±0.00 0.376±0.13
ENSMUST00000182316 0.076±0.00 N/A
ENSMUST00000182588 1.806±0.00 N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00038U CIL_00038U_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0002027 IMP regulation of heart rate
GO:0003283 IEA atrial septum development
GO:0005200 IEA structural constituent of cytoskeleton
GO:0005515 IPI protein binding
GO:0005622 IMP intracellular
GO:0005737 IDA cytoplasm
GO:0005856 IEA cytoskeleton
GO:0005886 IMP plasma membrane
GO:0005887 IDA integral component of plasma membrane
GO:0006874 IMP cellular calcium ion homeostasis
GO:0007165 IEA signal transduction
GO:0007399 IEA nervous system development
GO:0008104 IMP protein localization
GO:0010628 IMP positive regulation of gene expression
GO:0010881 IC regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882 IMP regulation of cardiac muscle contraction by calcium ion signaling
GO:0014704 IDA intercalated disc
GO:0015459 IMP potassium channel regulator activity
GO:0016323 IEA basolateral plasma membrane
GO:0019899 IEA enzyme binding
GO:0019901 IEA protein kinase binding
GO:0030018 IDA Z disc
GO:0030315 IDA T-tubule
GO:0030507 IEA spectrin binding
GO:0030674 IDA protein binding, bridging
GO:0030913 IEA paranodal junction assembly
GO:0031430 IDA M band
GO:0031647 IC regulation of protein stability
GO:0031672 IDA A band
GO:0033292 IMP T-tubule organization
GO:0033365 IEA protein localization to organelle
GO:0034394 IMP protein localization to cell surface
GO:0034613 IMP cellular protein localization
GO:0036309 IMP protein localization to M-band
GO:0036371 IMP protein localization to T-tubule
GO:0042383 IDA sarcolemma
GO:0042981 RCA regulation of apoptotic process
GO:0043005 IEA neuron projection
GO:0043034 IDA costamere
GO:0043268 IMP positive regulation of potassium ion transport
GO:0044325 IPI ion channel binding
GO:0045121 IEA membrane raft
GO:0045211 IEA postsynaptic membrane
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050821 IMP protein stabilization
GO:0051117 IPI ATPase binding
GO:0051279 IEA regulation of release of sequestered calcium ion into cytosol
GO:0051597 IEA response to methylmercury
GO:0051924 IMP regulation of calcium ion transport
GO:0051928 IMP positive regulation of calcium ion transport
GO:0055117 IMP regulation of cardiac muscle contraction
GO:0060048 IMP cardiac muscle contraction
GO:0060307 IEA regulation of ventricular cardiac muscle cell membrane repolarization
GO:0070972 IMP protein localization to endoplasmic reticulum
GO:0072659 IMP protein localization to plasma membrane
GO:0072661 IGI protein targeting to plasma membrane
GO:0086004 IMP regulation of cardiac muscle cell contraction
GO:0086005 IEA ventricular cardiac muscle cell action potential
GO:0086014 IMP atrial cardiac muscle cell action potential
GO:0086015 IMP SA node cell action potential
GO:0086036 IGI regulation of cardiac muscle cell membrane potential
GO:0086066 IMP atrial cardiac muscle cell to AV node cell communication
GO:0086070 IMP SA node cell to atrial cardiac muscle cell communication
GO:0086091 IMP regulation of heart rate by cardiac conduction
GO:1901018 IMP positive regulation of potassium ion transmembrane transporter activity
GO:1901019 IMP regulation of calcium ion transmembrane transporter activity
GO:1901021 IMP positive regulation of calcium ion transmembrane transporter activity
GO:2001257 IMP regulation of cation channel activity
GO:2001259 IMP positive regulation of cation channel activity

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000009026 CR388002.1 protein_coding Danio_rerio
ENSDARG00000043313 ank2b protein_coding Danio_rerio
ENSG00000145362 ANK2 ankyrin 2, neuronal protein_coding Homo_sapiens

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