ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: ATM serine/threonine kinase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000149311 ATM 9606 + 11:108222484-108369102 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000278616 ATM-201 108222832-108369099 protein_coding
  ENST00000419286 ATM-009 108268410-108271352 processed_transcript
  ENST00000452508 ATM-003 108223116-108369102 protein_coding
  ENST00000524792 ATM-011 108287392-108366034 retained_intron
  ENST00000525012 ATM-005 108252821-108253996 processed_transcript
  ENST00000525056 ATM-022 108332777-108336153 retained_intron
  ENST00000525178 ATM-023 108346521-108365729 processed_transcript
  ENST00000525537 ATM-020 108327394-108329238 retained_intron
  ENST00000526567 ATM-004 108223529-108229364 protein_coding
  ENST00000527181 ATM-024 108353756-108365738 retained_intron
  ENST00000527389 ATM-021 108327645-108329307 retained_intron
  ENST00000527805 ATM-001 108222484-108287714 protein_coding
  ENST00000527891 ATM-026 108223085-108244084 protein_coding
  ENST00000529588 ATM-014 108303022-108315894 nonsense_mediated_decay
  ENST00000530958 ATM-002 108223103-108236534 protein_coding
  ENST00000531525 ATM-012 108287600-108295996 protein_coding
  ENST00000531957 ATM-017 108293385-108295370 retained_intron
  ENST00000532765 ATM-019 108307992-108317467 processed_transcript
  ENST00000532931 ATM-016 108223090-108229272 protein_coding
  ENST00000533526 ATM-006 108252821-108253996 processed_transcript
  ENST00000533690 ATM-015 108296974-108333908 retained_intron
  ENST00000533733 ATM-010 108287178-108290667 retained_intron
  ENST00000533979 ATM-025 108332762-108336408 processed_transcript
  ENST00000534625 ATM-018 108299480-108303029 retained_intron
  ENST00000601453 ATM-027 108224078-108235743 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000278616ENST00000452508ENST00000524792ENST00000527805ENST00000527891ENST00000530958
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000278616 N/A 1.848±1.52 1.364±0.00 1.563±1.01
ENST00000452508 N/A 1.965±1.22 4.820±0.00 2.443±1.54
ENST00000524792 N/A 3.313±2.74 N/A 1.516±0.92
ENST00000527805 N/A 5.648±3.73 N/A 8.263±6.25
ENST00000527891 6.431±0.00 N/A N/A N/A
ENST00000530958 N/A N/A N/A 5.427±4.45

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000077 IEA DNA damage checkpoint
GO:0000723 IEA telomere maintenance
GO:0000724 TAS double-strand break repair via homologous recombination
GO:0000781 IDA chromosome, telomeric region
GO:0001666 IEA response to hypoxia
GO:0001756 IEA somitogenesis
GO:0002331 ISS pre-B cell allelic exclusion
GO:0003677 IEA DNA binding
GO:0004672 IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004677 IDA DNA-dependent protein kinase activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005819 IEA spindle
GO:0006281 TAS DNA repair
GO:0006302 TAS double-strand break repair
GO:0006468 IDA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0006975 IDA DNA damage induced protein phosphorylation
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050 IMP cell cycle arrest
GO:0007094 IMP mitotic spindle assembly checkpoint
GO:0007131 TAS reciprocal meiotic recombination
GO:0007165 TAS signal transduction
GO:0007292 IEA female gamete generation
GO:0007420 IEA brain development
GO:0007507 IEA heart development
GO:0008630 IEA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010212 IEA:IDA response to ionizing radiation
GO:0016303 IMP 1-phosphatidylinositol-3-kinase activity
GO:0016572 IEA histone phosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0030889 IMP negative regulation of B cell proliferation
GO:0031410 IEA cytoplasmic vesicle
GO:0032403 IDA protein complex binding
GO:0033151 IEA V(D)J recombination
GO:0035174 IEA histone serine kinase activity
GO:0035404 IEA histone-serine phosphorylation
GO:0036092 IMP phosphatidylinositol-3-phosphate biosynthetic process
GO:0042159 IEA lipoprotein catabolic process
GO:0043065 IMP positive regulation of apoptotic process
GO:0043517 IMP positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0046777 IDA protein autophosphorylation
GO:0046983 IDA protein dimerization activity
GO:0047485 IDA protein N-terminus binding
GO:0048599 IEA oocyte development
GO:0051402 IEA neuron apoptotic process
GO:0051726 IEA regulation of cell cycle
GO:0071044 IDA histone mRNA catabolic process
GO:0071480 IDA cellular response to gamma radiation
GO:0072434 IMP signal transduction involved in mitotic G2 DNA damage checkpoint
GO:0090399 IEA:IMP replicative senescence

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000002385 atm protein_coding Danio_rerio
ENSMUSG00000034218 Atm protein_coding Mus_musculus

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