ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: ATM serine/threonine kinase
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000278616 ATM-201 ENSG00000149311 9606 + 11:108222832-108369099 protein_coding

Homo sapiens Ensembl GRCh38

Genome
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Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHMVEC-DHUVECENST00000278616
Transcript ID HAoEC HMVEC-D HUVEC
ENST00000278616 1.848±1.52 1.364±0.00 1.563±1.01

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000077 IEA DNA damage checkpoint
GO:0000723 IEA telomere maintenance
GO:0000724 TAS double-strand break repair via homologous recombination
GO:0000781 IDA chromosome, telomeric region
GO:0001666 IEA response to hypoxia
GO:0001756 IEA somitogenesis
GO:0002331 ISS pre-B cell allelic exclusion
GO:0003677 IEA DNA binding
GO:0004672 IEA protein kinase activity
GO:0004674 IDA:IEA protein serine/threonine kinase activity
GO:0004677 IDA DNA-dependent protein kinase activity
GO:0005488 IEA binding
GO:0005515 IPI:IEA protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005654 TAS nucleoplasm
GO:0005737 IEA cytoplasm
GO:0005819 IEA spindle
GO:0006281 TAS DNA repair
GO:0006302 TAS double-strand break repair
GO:0006468 IDA protein phosphorylation
GO:0006915 IEA apoptotic process
GO:0006974 IMP cellular response to DNA damage stimulus
GO:0006975 IDA DNA damage induced protein phosphorylation
GO:0006977 TAS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050 IMP cell cycle arrest
GO:0007094 IMP mitotic spindle assembly checkpoint
GO:0007131 TAS reciprocal meiotic recombination
GO:0007165 TAS signal transduction
GO:0007292 IEA female gamete generation
GO:0007420 IEA brain development
GO:0007507 IEA heart development
GO:0008630 IEA intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010212 IEA:IDA response to ionizing radiation
GO:0016303 IMP 1-phosphatidylinositol-3-kinase activity
GO:0016572 IEA histone phosphorylation
GO:0016772 IEA transferase activity, transferring phosphorus-containing groups
GO:0016773 IEA phosphotransferase activity, alcohol group as acceptor
GO:0018105 IDA peptidyl-serine phosphorylation
GO:0030889 IMP negative regulation of B cell proliferation
GO:0031410 IEA cytoplasmic vesicle
GO:0032403 IDA protein complex binding
GO:0033151 IEA V(D)J recombination
GO:0035174 IEA histone serine kinase activity
GO:0035404 IEA histone-serine phosphorylation
GO:0036092 IMP phosphatidylinositol-3-phosphate biosynthetic process
GO:0042159 IEA lipoprotein catabolic process
GO:0043065 IMP positive regulation of apoptotic process
GO:0043517 IMP positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043525 IEA positive regulation of neuron apoptotic process
GO:0046777 IDA protein autophosphorylation
GO:0046983 IDA protein dimerization activity
GO:0047485 IDA protein N-terminus binding
GO:0048599 IEA oocyte development
GO:0051402 IEA neuron apoptotic process
GO:0051726 IEA regulation of cell cycle
GO:0071044 IDA histone mRNA catabolic process
GO:0071480 IDA cellular response to gamma radiation
GO:0072434 IMP signal transduction involved in mitotic G2 DNA damage checkpoint
GO:0090399 IEA:IMP replicative senescence

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000118282 Atm-001 protein_coding Mus_musculus 0 9226
ENSMUST00000132403 Atm-002 retained_intron Mus_musculus 0 1057
ENSMUST00000132249 Atm-004 protein_coding Mus_musculus 0 516
ENSMUST00000150244 Atm-003 protein_coding Mus_musculus 0 514

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