ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: SH3 and multiple ankyrin repeat domains 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000161681 SHANK1 9606 - 19:50661827-50719450 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000293441 SHANK1-001 50661827-50716938 protein_coding
  ENST00000359082 SHANK1-008 50661965-50716919 protein_coding
  ENST00000391813 SHANK1-003 50661827-50689404 protein_coding
  ENST00000391814 SHANK1-002 50661941-50719450 protein_coding
  ENST00000461154 SHANK1-005 50703699-50704506 retained_intron
  ENST00000468654 SHANK1-006 50662630-50666733 nonsense_mediated_decay
  ENST00000483128 SHANK1-004 50711027-50713948 retained_intron
  ENST00000483981 SHANK1-007 50662334-50663169 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000293441ENST00000359082ENST00000391813ENST00000391814ENST00000461154ENST00000468654ENST00000483128ENST00000483981
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000293441 N/A 0.303±0.09 0.037±0.00 N/A 0.045±0.04
ENST00000359082 N/A 0.440±0.25 N/A 0.278±0.00 0.064±0.05
ENST00000391813 0.189±0.10 0.328±0.00 N/A N/A 0.017±0.01
ENST00000391814 N/A 0.293±0.23 N/A N/A 0.050±0.04
ENST00000461154 N/A N/A N/A N/A 0.152±0.01
ENST00000468654 0.832±0.00 N/A N/A N/A 0.203±0.00
ENST00000483128 0.557±0.00 N/A N/A N/A 0.294±0.12
ENST00000483981 N/A N/A N/A N/A 0.188±0.00

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0005515 IPI:IEA protein binding
GO:0005622 NAS intracellular
GO:0005737 IEA cytoplasm
GO:0005886 ISS plasma membrane
GO:0006461 ISS protein complex assembly
GO:0007016 NAS cytoskeletal anchoring at plasma membrane
GO:0007616 ISS long-term memory
GO:0008022 ISS protein C-terminus binding
GO:0008306 ISS associative learning
GO:0008328 ISS ionotropic glutamate receptor complex
GO:0016020 IDA membrane
GO:0017124 ISS SH3 domain binding
GO:0017146 ISS N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054 IEA cell junction
GO:0030159 IEA receptor signaling complex scaffold activity
GO:0030160 ISS GKAP/Homer scaffold activity
GO:0030425 NAS dendrite
GO:0030534 IMP adult behavior
GO:0031877 ISS somatostatin receptor binding
GO:0032232 ISS negative regulation of actin filament bundle assembly
GO:0032403 ISS protein complex binding
GO:0035176 IMP social behavior
GO:0035255 ISS ionotropic glutamate receptor binding
GO:0035418 ISS protein localization to synapse
GO:0042048 IEA olfactory behavior
GO:0042802 ISS identical protein binding
GO:0043005 ISS neuron projection
GO:0043197 ISS dendritic spine
GO:0045202 IEA synapse
GO:0045211 ISS postsynaptic membrane
GO:0046959 IEA habituation
GO:0050885 ISS neuromuscular process controlling balance
GO:0050894 IMP determination of affect
GO:0060013 IEA righting reflex
GO:0060074 ISS synapse maturation
GO:0060076 ISS excitatory synapse
GO:0060997 ISS dendritic spine morphogenesis
GO:0060999 ISS positive regulation of dendritic spine development
GO:0071532 ISS ankyrin repeat binding
GO:0071625 IMP vocalization behavior
GO:0097110 ISS scaffold protein binding
GO:0097481 ISS neuronal postsynaptic density
GO:2000311 ISS regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463 ISS positive regulation of excitatory postsynaptic membrane potential

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000060539 shank1 protein_coding Danio_rerio
ENSMUSG00000038738 Shank1 protein_coding Mus_musculus

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