ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: DLC1 Rho GTPase activating protein
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000164741 DLC1 9606 - 8:13083361-13515658 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000276297 DLC1-001 13083361-13514886 protein_coding
  ENST00000316609 DLC1-003 13214575-13514765 protein_coding
  ENST00000358919 DLC1-002 13085189-13133474 protein_coding
  ENST00000503161 DLC1-016 13100606-13276873 protein_coding
  ENST00000506171 DLC1-010 13214267-13276310 processed_transcript
  ENST00000509922 DLC1-009 13100560-13276784 processed_transcript
  ENST00000510250 DLC1-017 13094929-13100905 retained_intron
  ENST00000510318 DLC1-006 13085555-13096037 processed_transcript
  ENST00000511869 DLC1-004 13304577-13514887 protein_coding
  ENST00000512044 DLC1-005 13085577-13276546 protein_coding
  ENST00000513883 DLC1-007 13094823-13096078 processed_transcript
  ENST00000515225 DLC1-012 13100689-13133289 processed_transcript
  ENST00000517333 DLC1-013 13499822-13515658 processed_transcript
  ENST00000517868 DLC1-019 13498859-13499241 protein_coding
  ENST00000520226 DLC1-008 13085593-13116244 protein_coding
  ENST00000521730 DLC1-018 13086232-13088739 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHUVECENST00000276297ENST00000358919ENST00000510250ENST00000512044ENST00000520226
Transcript ID HAoEC HUVEC
ENST00000276297 10.547±0.00 5.347±2.73
ENST00000358919 N/A 8.715±4.05
ENST00000510250 N/A 6.473±3.02
ENST00000512044 6.799±0.00 10.050±4.60
ENST00000520226 7.780±1.35 N/A

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0003VG CIL_0003VG_0001 CGP
CIL_000274 CIL_000274_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001843 ISS neural tube closure
GO:0003007 ISS heart morphogenesis
GO:0005100 IMP Rho GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005622 IEA intracellular
GO:0005634 IDA nucleus
GO:0005737 IDA cytoplasm
GO:0005829 TAS cytosol
GO:0005901 IDA caveola
GO:0005925 IDA focal adhesion
GO:0006915 IDA apoptotic process
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 IEA signal transduction
GO:0007264 TAS small GTPase mediated signal transduction
GO:0008285 IDA negative regulation of cell proliferation
GO:0008289 IEA lipid binding
GO:0008360 IMP regulation of cell shape
GO:0021575 ISS hindbrain morphogenesis
GO:0030036 ISS actin cytoskeleton organization
GO:0030336 IMP negative regulation of cell migration
GO:0030900 ISS forebrain development
GO:0032321 IMP positive regulation of Rho GTPase activity
GO:0032956 IMP regulation of actin cytoskeleton organization
GO:0035024 IMP negative regulation of Rho protein signal transduction
GO:0035307 IDA positive regulation of protein dephosphorylation
GO:0042169 IPI SH2 domain binding
GO:0048041 ISS focal adhesion assembly
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0051497 IDA negative regulation of stress fiber assembly
GO:1900119 IDA positive regulation of execution phase of apoptosis

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000079317 DLC1 protein_coding Danio_rerio
ENSMUSG00000031523 Dlc1 protein_coding Mus_musculus

Loading