ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: SMAD family member 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000170365 SMAD1 9606 + 4:145481194-145558079 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000302085 SMAD1-001 145481792-145558079 protein_coding
  ENST00000394092 SMAD1-015 145482805-145557954 protein_coding
  ENST00000502342 SMAD1-011 145525720-145539969 processed_transcript
  ENST00000503324 SMAD1-006 145482486-145514788 protein_coding
  ENST00000506626 SMAD1-017 145484513-145514703 processed_transcript
  ENST00000507367 SMAD1-012 145482792-145514643 protein_coding
  ENST00000507594 SMAD1-004 145481306-145514900 protein_coding
  ENST00000510948 SMAD1-018 145546077-145554035 processed_transcript
  ENST00000511125 SMAD1-014 145544178-145558079 retained_intron
  ENST00000511255 SMAD1-019 145546520-145553917 retained_intron
  ENST00000512019 SMAD1-007 145481871-145515013 protein_coding
  ENST00000514168 SMAD1-013 145482813-145514493 processed_transcript
  ENST00000514778 SMAD1-003 145481194-145514932 protein_coding
  ENST00000514831 SMAD1-005 145481698-145514951 protein_coding
  ENST00000515385 SMAD1-002 145482811-145558079 protein_coding
  ENST00000515527 SMAD1-016 145482498-145514746 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHUVECENST00000302085ENST00000394092ENST00000503324ENST00000511125ENST00000515385
Transcript ID BECs HAoEC HUVEC
ENST00000302085 1.098±0.00 3.197±3.04 10.645±5.01
ENST00000394092 N/A N/A 28.232±8.10
ENST00000503324 1.189±0.00 N/A N/A
ENST00000511125 N/A N/A 3.010±0.01
ENST00000515385 N/A N/A 10.800±7.33

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 IEA MAPK cascade
GO:0000979 IEA RNA polymerase II core promoter sequence-specific DNA binding
GO:0001657 IEA ureteric bud development
GO:0001710 IEA mesodermal cell fate commitment
GO:0001822 IEA kidney development
GO:0002051 IEA osteoblast fate commitment
GO:0003700 IDA:IEA sequence-specific DNA binding transcription factor activity
GO:0005057 NAS receptor signaling protein activity
GO:0005515 IPI:IEA protein binding
GO:0005622 NAS:IEA intracellular
GO:0005634 IDA nucleus
GO:0005637 IDA nuclear inner membrane
GO:0005654 TAS nucleoplasm
GO:0005667 IEA transcription factor complex
GO:0005737 IDA cytoplasm
GO:0005739 IDA mitochondrion
GO:0005829 TAS cytosol
GO:0006351 IEA transcription, DNA-templated
GO:0006355 IEA regulation of transcription, DNA-templated
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006468 IEA protein phosphorylation
GO:0006954 IEA inflammatory response
GO:0007165 NAS signal transduction
GO:0007179 IEA:NAS transforming growth factor beta receptor signaling pathway
GO:0007183 IDA SMAD protein complex assembly
GO:0007276 IEA gamete generation
GO:0008285 IEA negative regulation of cell proliferation
GO:0009880 ISS embryonic pattern specification
GO:0010243 IEA response to organonitrogen compound
GO:0010628 IDA positive regulation of gene expression
GO:0010656 IEA negative regulation of muscle cell apoptotic process
GO:0016021 NAS integral component of membrane
GO:0019901 IPI protein kinase binding
GO:0030509 ISS BMP signaling pathway
GO:0030618 TAS transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0030901 IEA midbrain development
GO:0030902 IEA hindbrain development
GO:0031053 TAS primary miRNA processing
GO:0042060 IEA wound healing
GO:0042493 IEA response to drug
GO:0042592 IEA homeostatic process
GO:0042802 IPI identical protein binding
GO:0043234 IDA protein complex
GO:0045597 IEA positive regulation of cell differentiation
GO:0045669 IEA positive regulation of osteoblast differentiation
GO:0045944 IC positive regulation of transcription from RNA polymerase II promoter
GO:0046872 IEA metal ion binding
GO:0050775 IEA positive regulation of dendrite morphogenesis
GO:0051216 IEA cartilage development
GO:0060038 IEA cardiac muscle cell proliferation
GO:0060348 IEA bone development
GO:0061036 IEA positive regulation of cartilage development
GO:0070410 IPI co-SMAD binding
GO:0070411 IPI I-SMAD binding
GO:0071407 IEA cellular response to organic cyclic compound
GO:0071773 ISS cellular response to BMP stimulus
GO:1901522 ISS positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSMUSG00000031681 Smad1 protein_coding Mus_musculus

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