ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: SIX homeobox 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000170577 SIX2 9606 - 2:45005161-45009430 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000303077 SIX2-001 45005161-45009430 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000303077
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000303077 0.707±0.16 0.860±0.44 0.255±0.00 0.311±0.49

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0007KD CIL_0007KD_0001 UCNEbase
CIL_00083B CIL_00083B_0001 VISTA
CIL_0009CD CIL_0009CD_0001 VISTA
CIL_0009CC CIL_0009CC_0001 VISTA
CIL_0007WX CIL_0007WX_0001 VISTA
CIL_0001NN CIL_0001NN_0001 CGP
CIL_0000RS CIL_0000RS_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001656 IEA metanephros development
GO:0001822 ISS kidney development
GO:0002062 IEA chondrocyte differentiation
GO:0003337 ISS mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0003677 IEA DNA binding
GO:0003700 IEA sequence-specific DNA binding transcription factor activity
GO:0005515 IEA protein binding
GO:0005634 IEA nucleus
GO:0006606 IEA protein import into nucleus
GO:0007501 ISS mesodermal cell fate specification
GO:0008134 IEA transcription factor binding
GO:0008283 IDA cell proliferation
GO:0009653 TAS anatomical structure morphogenesis
GO:0009948 ISS anterior/posterior axis specification
GO:0016477 IDA cell migration
GO:0030278 IEA regulation of ossification
GO:0032330 IEA regulation of chondrocyte differentiation
GO:0032403 IEA protein complex binding
GO:0042474 IEA middle ear morphogenesis
GO:0043565 IEA sequence-specific DNA binding
GO:0045596 IEA negative regulation of cell differentiation
GO:0045944 IEA positive regulation of transcription from RNA polymerase II promoter
GO:0048557 ISS embryonic digestive tract morphogenesis
GO:0048701 IEA embryonic cranial skeleton morphogenesis
GO:0048704 IEA embryonic skeletal system morphogenesis
GO:0072006 ISS nephron development
GO:0072028 ISS nephron morphogenesis
GO:0072038 ISS mesenchymal stem cell maintenance involved in nephron morphogenesis
GO:0072161 ISS mesenchymal cell differentiation involved in kidney development
GO:0090189 ISS regulation of branching involved in ureteric bud morphogenesis
GO:0097168 ISS mesenchymal stem cell proliferation
GO:1902732 ISS positive regulation of chondrocyte proliferation

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000058004 six2a protein_coding Danio_rerio
ENSMUSG00000024134 Six2 protein_coding Mus_musculus

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