ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: heparanase
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000173083 HPSE 9606 - 4:83292461-83335153 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000311412 HPSE-002 83292461-83334882 protein_coding
  ENST00000405413 HPSE-001 83292461-83335153 protein_coding
  ENST00000507150 HPSE-004 83295320-83335153 nonsense_mediated_decay
  ENST00000508891 HPSE-007 83295320-83335153 nonsense_mediated_decay
  ENST00000509906 HPSE-006 83295320-83335153 nonsense_mediated_decay
  ENST00000512196 HPSE-005 83295320-83335153 protein_coding
  ENST00000513463 HPSE-003 83295344-83334782 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000311412ENST00000507150ENST00000508891ENST00000509906ENST00000512196ENST00000513463
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000311412 0.390±0.00 8.417±4.43 7.232±0.00 1.336±0.93
ENST00000507150 0.690±0.00 5.602±2.38 4.251±0.00 1.036±0.61
ENST00000508891 1.243±0.00 N/A N/A 1.344±0.24
ENST00000509906 N/A 4.647±2.98 N/A 1.733±1.19
ENST00000512196 N/A 3.702±0.00 3.838±0.00 1.305±0.74
ENST00000513463 1.736±0.00 6.870±3.91 N/A 3.678±1.40

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00069P CIL_00069P_0001 CGP
CIL_0006JB CIL_0006JB_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0004566 TAS beta-glucuronidase activity
GO:0005515 IPI protein binding
GO:0005576 IEA extracellular region
GO:0005634 IDA nucleus
GO:0005764 IDA lysosome
GO:0005975 TAS carbohydrate metabolic process
GO:0006027 TAS glycosaminoglycan catabolic process
GO:0006029 TAS proteoglycan metabolic process
GO:0007160 IDA cell-matrix adhesion
GO:0008152 IEA metabolic process
GO:0010575 IDA positive regulation vascular endothelial growth factor production
GO:0016020 IEA membrane
GO:0016798 IEA hydrolase activity, acting on glycosyl bonds
GO:0030194 IDA positive regulation of blood coagulation
GO:0030200 IDA heparan sulfate proteoglycan catabolic process
GO:0030203 TAS glycosaminoglycan metabolic process
GO:0030305 IDA heparanase activity
GO:0033690 IDA positive regulation of osteoblast proliferation
GO:0042060 IEA wound healing
GO:0043202 TAS lysosomal lumen
GO:0043231 IDA intracellular membrane-bounded organelle
GO:0044281 TAS small molecule metabolic process
GO:0045121 IEA membrane raft
GO:0045545 IDA syndecan binding
GO:0046983 IDA protein dimerization activity
GO:0051797 IDA regulation of hair follicle development
GO:0051798 IEA positive regulation of hair follicle development
GO:0051897 IDA positive regulation of protein kinase B signaling
GO:0060055 IEA angiogenesis involved in wound healing
GO:0061042 IEA vascular wound healing

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000063634 hpse protein_coding Danio_rerio
ENSMUSG00000035273 Hpse protein_coding Mus_musculus

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