ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: Rho guanine nucleotide exchange factor (GEF) 12
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000196914 ARHGEF12 9606 + 11:120336914-120489936 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000356641 ARHGEF12-015 120336914-120487060 protein_coding
  ENST00000397843 ARHGEF12-001 120337078-120489936 protein_coding
  ENST00000525222 ARHGEF12-012 120449275-120459194 retained_intron
  ENST00000525960 ARHGEF12-009 120445422-120447266 retained_intron
  ENST00000526067 ARHGEF12-014 120475975-120480107 retained_intron
  ENST00000528225 ARHGEF12-008 120438448-120451633 retained_intron
  ENST00000528681 ARHGEF12-007 120477000-120477573 retained_intron
  ENST00000529970 ARHGEF12-006 120385321-120477646 retained_intron
  ENST00000530388 ARHGEF12-005 120405933-120411837 retained_intron
  ENST00000530747 ARHGEF12-013 120457718-120467308 retained_intron
  ENST00000531616 ARHGEF12-010 120462549-120473127 retained_intron
  ENST00000532823 ARHGEF12-011 120448494-120457752 retained_intron
  ENST00000532993 ARHGEF12-003 120385294-120489034 protein_coding
  ENST00000612968 ARHGEF12-016 120457051-120459339 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHMVEC-DHUVECENST00000356641ENST00000397843ENST00000532993
Transcript ID HAoEC HMVEC-D HUVEC
ENST00000356641 10.075±4.41 8.408±0.00 10.117±5.66
ENST00000397843 4.234±1.80 N/A 2.023±0.66
ENST00000532993 18.127±4.87 14.686±0.00 10.074±5.72

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00021Z CIL_00021Z_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001664 IDA G-protein coupled receptor binding
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005096 IEA GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005737 IEA:IDA cytoplasm
GO:0005829 TAS cytosol
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007411 TAS axon guidance
GO:0016020 IEA membrane
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0038032 IEA termination of G-protein coupled receptor signaling pathway
GO:0043065 TAS positive regulation of apoptotic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0070062 IDA extracellular vesicular exosome
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000030532 ARHGEF12 (1 of 2) protein_coding Danio_rerio
ENSMUSG00000059495 Arhgef12 protein_coding Mus_musculus

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