ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: Rho guanine nucleotide exchange factor (GEF) 12
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000397843 ARHGEF12-001 ENSG00000196914 9606 + 11:120337078-120489936 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; HAoECHUVECENST00000397843
Transcript ID HAoEC HUVEC
ENST00000397843 4.234±1.80 2.023±0.66

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0001664 IDA G-protein coupled receptor binding
GO:0005089 IEA Rho guanyl-nucleotide exchange factor activity
GO:0005096 IEA GTPase activator activity
GO:0005515 IPI:IEA protein binding
GO:0005737 IEA:IDA cytoplasm
GO:0005829 TAS cytosol
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007264 TAS small GTPase mediated signal transduction
GO:0007411 TAS axon guidance
GO:0016020 IEA membrane
GO:0032321 IEA positive regulation of Rho GTPase activity
GO:0035023 IEA regulation of Rho protein signal transduction
GO:0035556 IEA intracellular signal transduction
GO:0038032 IEA termination of G-protein coupled receptor signaling pathway
GO:0043065 TAS positive regulation of apoptotic process
GO:0048011 TAS neurotrophin TRK receptor signaling pathway
GO:0051056 TAS regulation of small GTPase mediated signal transduction
GO:0070062 IDA extracellular vesicular exosome
GO:0097190 TAS apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000165665 Arhgef12-202 protein_coding Mus_musculus 0 6527
ENSMUST00000072767 Arhgef12-201 protein_coding Mus_musculus 0 6239

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