ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000025340 Rabgef1 10090 + 5:130171798-130214342 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000026390 Rabgef1-002 130187161-130214337 protein_coding
  ENSMUST00000119027 Rabgef1-004 130187161-130208752 protein_coding
  ENSMUST00000119797 Rabgef1-001 130171798-130214342 protein_coding
  ENSMUST00000125937 Rabgef1-006 130207053-130210991 retained_intron
  ENSMUST00000143727 Rabgef1-005 130187220-130191321 retained_intron
  ENSMUST00000143865 Rabgef1-008 130213166-130214050 nonsense_mediated_decay
  ENSMUST00000147493 Rabgef1-007 130211381-130212975 retained_intron
  ENSMUST00000148264 Rabgef1-003 130171824-130210442 protein_coding
  ENSMUST00000202729 Rabgef1-009 130187208-130207090 processed_transcript

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000119797ENSMUST00000148264
Transcript ID C166 Tie2+ EC mES
ENSMUST00000119797 15.056±4.15 9.952±8.92 0.600±0.00
ENSMUST00000148264 6.907±0.32 N/A 0.856±0.00

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0005UP CIL_0005UP_0002 CGP
CIL_000256 CIL_000256_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001933 IMP negative regulation of protein phosphorylation
GO:0002686 IMP negative regulation of leukocyte migration
GO:0003677 IEA DNA binding
GO:0004842 IDA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005768 IEA endosome
GO:0005769 IEA early endosome
GO:0006612 IEA protein targeting to membrane
GO:0006897 IEA endocytosis
GO:0008270 IEA zinc ion binding
GO:0015031 IEA protein transport
GO:0016567 IDA protein ubiquitination
GO:0017112 IEA Rab guanyl-nucleotide exchange factor activity
GO:0017137 IEA Rab GTPase binding
GO:0031982 IDA vesicle
GO:0032851 IEA positive regulation of Rab GTPase activity
GO:0033004 IMP negative regulation of mast cell activation
GO:0043305 IMP negative regulation of mast cell degranulation
GO:0046580 IMP negative regulation of Ras protein signal transduction
GO:0048261 IMP negative regulation of receptor-mediated endocytosis
GO:0050728 IMP negative regulation of inflammatory response
GO:0060368 IMP regulation of Fc receptor mediated stimulatory signaling pathway
GO:1900165 IMP negative regulation of interleukin-6 secretion
GO:1900235 IMP negative regulation of Kit signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014430 rabgef1 protein_coding Danio_rerio
ENSDARG00000015968 rabgef1l protein_coding Danio_rerio
ENSG00000154710 RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 protein_coding Homo_sapiens

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