ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: RAB guanine nucleotide exchange factor (GEF) 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000154710 RABGEF1 9606 + 7:66682164-66811464 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000284957 RABGEF1-001 66740733-66811464 protein_coding
  ENST00000380828 RABGEF1-201 66755882-66811459 protein_coding
  ENST00000437078 RABGEF1-202 66739975-66811459 protein_coding
  ENST00000439720 RABGEF1-003 66755889-66810667 protein_coding
  ENST00000442563 RABGEF1-005 66740733-66772035 protein_coding
  ENST00000450873 RABGEF1-002 66740733-66809817 protein_coding
  ENST00000461017 RABGEF1-006 66797372-66808064 processed_transcript
  ENST00000484547 RABGEF1-004 66771883-66811193 processed_transcript
  ENST00000510829 RABGEF1-203 66740656-66811459 protein_coding
  ENST00000607882 RABGEF1-007 66682164-66809662 nonsense_mediated_decay

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000439720ENST00000450873ENST00000461017ENST00000607882
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000439720 N/A 1.074±0.00 N/A N/A 2.054±0.00
ENST00000450873 N/A 2.628±0.88 4.122±0.00 2.486±0.00 3.543±0.83
ENST00000461017 N/A N/A N/A N/A 6.056±1.15
ENST00000607882 5.426±2.46 2.224±0.43 N/A 2.286±0.00 3.985±1.16

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00024I CIL_00024I_0001 CGP
CIL_0005UP CIL_0005UP_0001 CGP
CIL_000256 CIL_000256_0001 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001933 IEA negative regulation of protein phosphorylation
GO:0002686 IEA negative regulation of leukocyte migration
GO:0003677 IEA DNA binding
GO:0004842 IEA ubiquitin-protein transferase activity
GO:0005515 IPI protein binding
GO:0005769 IMP early endosome
GO:0006612 IMP protein targeting to membrane
GO:0006897 IEA endocytosis
GO:0008270 IEA zinc ion binding
GO:0016567 IEA protein ubiquitination
GO:0017112 IDA Rab guanyl-nucleotide exchange factor activity
GO:0017137 IPI Rab GTPase binding
GO:0031982 IEA vesicle
GO:0032851 IDA positive regulation of Rab GTPase activity
GO:0033004 IEA negative regulation of mast cell activation
GO:0043305 IEA negative regulation of mast cell degranulation
GO:0046580 IEA negative regulation of Ras protein signal transduction
GO:0048261 IEA negative regulation of receptor-mediated endocytosis
GO:0050728 IEA negative regulation of inflammatory response
GO:0060368 IEA regulation of Fc receptor mediated stimulatory signaling pathway
GO:1900165 IEA negative regulation of interleukin-6 secretion
GO:1900235 IEA negative regulation of Kit signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000014430 rabgef1 protein_coding Danio_rerio
ENSDARG00000015968 rabgef1l protein_coding Danio_rerio
ENSMUSG00000025340 Rabgef1 protein_coding Mus_musculus

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