ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032350 Gclc 10090 + 9:77754535-77794485 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000034905 Gclc-001 77754535-77794485 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000034905
Transcript ID C166 Tie2+ EC mES
ENSMUST00000034905 13.919±4.23 6.905±1.94 8.774±0.74

Conserved Regions

Region IDSub-RegionRegion Type
CIL_000585 CIL_000585_0002 CGP
CIL_000588 CIL_000588_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000287 ISS magnesium ion binding
GO:0004357 ISS glutamate-cysteine ligase activity
GO:0005524 IEA ATP binding
GO:0005829 IDA cytosol
GO:0006534 ISS cysteine metabolic process
GO:0006536 ISS glutamate metabolic process
GO:0006749 IMP glutathione metabolic process
GO:0006750 ISS glutathione biosynthetic process
GO:0006979 ISS response to oxidative stress
GO:0008637 IGI apoptotic mitochondrial changes
GO:0009408 ISS response to heat
GO:0009410 IMP response to xenobiotic stimulus
GO:0009725 ISS response to hormone
GO:0016595 ISS glutamate binding
GO:0017109 IDA glutamate-cysteine ligase complex
GO:0019852 IMP L-ascorbic acid metabolic process
GO:0031397 IMP negative regulation of protein ubiquitination
GO:0032436 IMP positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043066 ISS negative regulation of apoptotic process
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043531 ISS ADP binding
GO:0045454 ISS cell redox homeostasis
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0046685 IMP response to arsenic-containing substance
GO:0046982 IPI protein heterodimerization activity
GO:0050662 ISS coenzyme binding
GO:0050880 ISS regulation of blood vessel size
GO:0051409 IEA response to nitrosative stress
GO:0051900 IGI regulation of mitochondrial depolarization
GO:2001237 IGI negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013095 gclc protein_coding Danio_rerio
ENSG00000001084 GCLC glutamate-cysteine ligase, catalytic subunit protein_coding Homo_sapiens

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