ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: glutamate-cysteine ligase, catalytic subunit
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000001084 GCLC 9606 - 6:53497341-53616970 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000229416 GCLC-001 53497341-53545129 protein_coding
  ENST00000504353 GCLC-012 53500200-53507078 retained_intron
  ENST00000504525 GCLC-008 53508597-53545088 nonsense_mediated_decay
  ENST00000505197 GCLC-013 53522465-53616970 protein_coding
  ENST00000505294 GCLC-007 53514207-53522779 nonsense_mediated_decay
  ENST00000509541 GCLC-005 53497341-53510448 retained_intron
  ENST00000510837 GCLC-011 53498772-53505664 retained_intron
  ENST00000513939 GCLC-009 53514287-53544608 protein_coding
  ENST00000514004 GCLC-003 53512989-53545033 protein_coding
  ENST00000514373 GCLC-010 53505261-53505895 protein_coding
  ENST00000514933 GCLC-006 53514335-53523324 protein_coding
  ENST00000515580 GCLC-004 53498142-53501350 retained_intron
  ENST00000616923 GCLC-201 53497346-53545129 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHUVECENST00000229416ENST00000509541ENST00000514004ENST00000616923
Transcript ID BECs HAoEC HHSEC HUVEC
ENST00000229416 N/A 3.490±1.52 N/A 2.484±0.95
ENST00000509541 0.235±0.00 N/A 1.195±0.00 1.393±0.42
ENST00000514004 N/A N/A N/A 1.391±0.09
ENST00000616923 0.226±0.00 N/A N/A N/A

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000096 TAS sulfur amino acid metabolic process
GO:0000287 IDA magnesium ion binding
GO:0004357 IEA:IDA glutamate-cysteine ligase activity
GO:0005524 IEA ATP binding
GO:0005737 IBA cytoplasm
GO:0005829 TAS cytosol
GO:0006534 IDA cysteine metabolic process
GO:0006536 IDA glutamate metabolic process
GO:0006749 IEA glutathione metabolic process
GO:0006750 IEA glutathione biosynthetic process
GO:0006805 TAS xenobiotic metabolic process
GO:0006979 IDA response to oxidative stress
GO:0008637 IEA apoptotic mitochondrial changes
GO:0009408 IDA response to heat
GO:0009410 IEA response to xenobiotic stimulus
GO:0009725 IDA response to hormone
GO:0016595 IDA glutamate binding
GO:0017109 IEA glutamate-cysteine ligase complex
GO:0019852 IEA L-ascorbic acid metabolic process
GO:0031397 IEA negative regulation of protein ubiquitination
GO:0032436 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043524 IEA negative regulation of neuron apoptotic process
GO:0043531 IDA ADP binding
GO:0044281 TAS small molecule metabolic process
GO:0045454 IDA cell redox homeostasis
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0046685 IEA response to arsenic-containing substance
GO:0046982 IEA protein heterodimerization activity
GO:0050662 IPI coenzyme binding
GO:0050880 IMP regulation of blood vessel size
GO:0051409 IEA response to nitrosative stress
GO:0051900 IEA regulation of mitochondrial depolarization
GO:1901687 TAS glutathione derivative biosynthetic process
GO:2001237 IEA negative regulation of extrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000013095 gclc protein_coding Danio_rerio
ENSMUSG00000032350 Gclc protein_coding Mus_musculus

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