ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000032633 Flcn 10090 - 11:59791408-59810016 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000047706 Flcn-002 59804522-59809994 protein_coding
  ENSMUST00000091246 Flcn-005 59791790-59809588 protein_coding
  ENSMUST00000102697 Flcn-004 59791408-59810016 protein_coding
  ENSMUST00000133647 Flcn-001 59803759-59809601 processed_transcript
  ENSMUST00000148151 Flcn-003 59791457-59809924 retained_intron
  ENSMUST00000151453 Flcn-006 59809028-59809711 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000091246ENSMUST00000102697ENSMUST00000148151
Transcript ID C166 Tie2+ EC mES
ENSMUST00000091246 12.597±1.63 2.356±2.14 N/A
ENSMUST00000102697 6.039±0.58 3.979±2.82 5.795±1.57
ENSMUST00000148151 N/A 2.763±0.00 1.604±0.41

Conserved Regions

Region IDSub-RegionRegion Type
CIL_0009A0 CIL_0009A0_0002 VISTA
CIL_0000NR CIL_0000NR_0002 CGP
CIL_00040N CIL_00040N_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter
GO:0001701 IMP in utero embryonic development
GO:0001932 ISS regulation of protein phosphorylation
GO:0001934 IMP positive regulation of protein phosphorylation
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005886 ISS plasma membrane
GO:0007043 IMP cell-cell junction assembly
GO:0010629 IMP negative regulation of gene expression
GO:0010823 IMP negative regulation of mitochondrion organization
GO:0016525 NAS negative regulation of angiogenesis
GO:0030097 IMP hemopoiesis
GO:0030308 ISS negative regulation of cell growth
GO:0030336 ISS negative regulation of cell migration
GO:0030496 ISS midbody
GO:0030511 IMP positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031929 ISS TOR signaling
GO:0032006 IMP regulation of TOR signaling
GO:0032007 IMP negative regulation of TOR signaling
GO:0032008 IMP positive regulation of TOR signaling
GO:0032403 ISS protein complex binding
GO:0032465 ISS regulation of cytokinesis
GO:0035024 ISS negative regulation of Rho protein signal transduction
GO:0035065 IMP regulation of histone acetylation
GO:0044291 ISS cell-cell contact zone
GO:0045785 ISS positive regulation of cell adhesion
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045944 ISS positive regulation of transcription from RNA polymerase II promoter
GO:0051898 IMP negative regulation of protein kinase B signaling
GO:0070373 IMP negative regulation of ERK1 and ERK2 cascade
GO:1900181 ISS negative regulation of protein localization to nucleus
GO:1901723 IMP negative regulation of cell proliferation involved in kidney development
GO:1901856 IMP negative regulation of cellular respiration
GO:1901859 IMP negative regulation of mitochondrial DNA metabolic process
GO:1901862 IMP negative regulation of muscle tissue development
GO:1901874 IMP negative regulation of post-translational protein modification
GO:2000506 IMP negative regulation of energy homeostasis
GO:2000973 IMP regulation of pro-B cell differentiation
GO:2001170 IMP negative regulation of ATP biosynthetic process
GO:2001244 IMP positive regulation of intrinsic apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000062385 flcn protein_coding Danio_rerio
ENSG00000154803 FLCN folliculin protein_coding Homo_sapiens
ENSG00000264187 RP11-45M22.4 Uncharacterized protein {ECO:0000313|Ensembl:ENSP00000394249} protein_coding Homo_sapiens

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