ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description:
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENSMUST00000066728 Pde5a-001 ENSMUSG00000053965 10090 + 3:122728947-122859374 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000066728
Transcript ID C166 Tie2+ EC mES
ENSMUST00000066728 1.273±0.30 2.423±1.48 1.690±0.27

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0004112 IDA cyclic-nucleotide phosphodiesterase activity
GO:0004114 IMP 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0007165 IEA signal transduction
GO:0010613 IMP positive regulation of cardiac muscle hypertrophy
GO:0030553 IDA cGMP binding
GO:0030823 IGI regulation of cGMP metabolic process
GO:0042130 IMP negative regulation of T cell proliferation
GO:0043406 IMP positive regulation of MAP kinase activity
GO:0045745 IC positive regulation of G-protein coupled receptor protein signaling pathway
GO:0046068 IMP cGMP metabolic process
GO:0046069 IEA cGMP catabolic process
GO:0046872 IEA metal ion binding
GO:0047555 IEA 3',5'-cyclic-GMP phosphodiesterase activity
GO:0055118 IMP negative regulation of cardiac muscle contraction
GO:0055119 IMP relaxation of cardiac muscle
GO:0060282 IGI positive regulation of oocyte development

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENST00000264805 PDE5A-002 protein_coding Homo_sapiens 0 3103
ENST00000354960 PDE5A-001 protein_coding Homo_sapiens 0 3205
ENST00000394439 PDE5A-201 protein_coding Homo_sapiens 0 3099
ENST00000420633 PDE5A-003 protein_coding Homo_sapiens 0 872
ENST00000503412 PDE5A-005 protein_coding Homo_sapiens 0 710
ENST00000509612 PDE5A-009 retained_intron Homo_sapiens 0 254
ENST00000512450 PDE5A-012 processed_transcript Homo_sapiens 0 448
ENST00000512494 PDE5A-006 retained_intron Homo_sapiens 0 283
ENST00000512739 PDE5A-008 processed_transcript Homo_sapiens 0 614
ENST00000513594 PDE5A-011 processed_transcript Homo_sapiens 0 545

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