ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: sortilin-related receptor, L(DLR class) A repeats containing
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000260197 SORL1-001 ENSG00000137642 9606 + 11:121452203-121633693 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHMVEC-DHUVECENST00000260197
Transcript ID BECs HAoEC HMVEC-D HUVEC
ENST00000260197 0.004±0.00 0.262±0.28 0.060±0.00 0.043±0.05

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000042 IDA protein targeting to Golgi
GO:0001540 IPI beta-amyloid binding
GO:0004888 TAS transmembrane signaling receptor activity
GO:0005515 IPI:IEA protein binding
GO:0005615 IDA extracellular space
GO:0005641 IDA nuclear envelope lumen
GO:0005768 IDA endosome
GO:0005769 IMP early endosome
GO:0005771 IEA multivesicular body
GO:0005783 IDA endoplasmic reticulum
GO:0005794 IDA Golgi apparatus
GO:0005802 IDA trans-Golgi network
GO:0005887 TAS integral component of plasma membrane
GO:0006605 IMP protein targeting
GO:0006622 IDA protein targeting to lysosome
GO:0006869 IEA lipid transport
GO:0006892 IDA post-Golgi vesicle-mediated transport
GO:0006898 TAS receptor-mediated endocytosis
GO:0007165 TAS signal transduction
GO:0008203 IEA cholesterol metabolic process
GO:0008219 IEA cell death
GO:0008283 IEA cell proliferation
GO:0014910 IDA regulation of smooth muscle cell migration
GO:0016020 IDA membrane
GO:0016021 IEA integral component of membrane
GO:0016477 IEA cell migration
GO:0030169 IPI low-density lipoprotein particle binding
GO:0030306 IPI ADP-ribosylation factor binding
GO:0031985 IDA Golgi cisterna
GO:0032091 IDA negative regulation of protein binding
GO:0032460 IMP negative regulation of protein oligomerization
GO:0034362 IEA low-density lipoprotein particle
GO:0043025 IEA neuronal cell body
GO:0043407 ISS negative regulation of MAP kinase activity
GO:0045053 IDA protein retention in Golgi apparatus
GO:0045732 IDA positive regulation of protein catabolic process
GO:0050768 ISS negative regulation of neurogenesis
GO:0051604 IDA protein maturation
GO:0055037 IMP recycling endosome
GO:0070062 IDA extracellular vesicular exosome
GO:0070863 IMP positive regulation of protein exit from endoplasmic reticulum
GO:1901215 ISS negative regulation of neuron death
GO:1902430 IDA negative regulation of beta-amyloid formation
GO:1902771 ISS positive regulation of choline O-acetyltransferase activity
GO:1902948 ISS negative regulation of tau-protein kinase activity
GO:1902953 IMP positive regulation of ER to Golgi vesicle-mediated transport
GO:1902955 IMP positive regulation of early endosome to recycling endosome transport
GO:1902960 IDA negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 IMP negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902966 IMP positive regulation of protein localization to early endosome
GO:1902997 ISS negative regulation of neurofibrillary tangle assembly
GO:2001137 IMP positive regulation of endocytic recycling

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000060989 Sorl1-001 protein_coding Mus_musculus 0 8419
ENSMUST00000148800 Sorl1-003 retained_intron Mus_musculus 0 590

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