ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: histone deacetylase 6
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000334136 HDAC6-001 ENSG00000094631 9606 + X:48801995-48824976 protein_coding

Homo sapiens Ensembl GRCh38

Genome
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Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000334136
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000334136 1.566±0.00 2.985±0.94 3.988±0.00 8.438±0.00 7.010±3.98

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000118 IDA histone deacetylase complex
GO:0000209 IEA protein polyubiquitination
GO:0001047 IDA core promoter binding
GO:0003779 IEA actin binding
GO:0004407 IDA histone deacetylase activity
GO:0005515 IPI protein binding
GO:0005634 ISS nucleus
GO:0005737 ISS cytoplasm
GO:0005829 ISS cytosol
GO:0005874 IDA microtubule
GO:0005875 IDA microtubule associated complex
GO:0005881 IEA cytoplasmic microtubule
GO:0005901 IDA caveola
GO:0006351 IEA transcription, DNA-templated
GO:0006476 IMP protein deacetylation
GO:0006511 IEA ubiquitin-dependent protein catabolic process
GO:0006515 IMP misfolded or incompletely synthesized protein catabolic process
GO:0006886 IMP intracellular protein transport
GO:0007026 IEA negative regulation of microtubule depolymerization
GO:0008013 IPI beta-catenin binding
GO:0008017 ISS microtubule binding
GO:0008270 IEA zinc ion binding
GO:0009636 IMP response to toxic substance
GO:0009967 IMP positive regulation of signal transduction
GO:0010033 IMP response to organic substance
GO:0010469 IMP regulation of receptor activity
GO:0010634 IMP positive regulation of epithelial cell migration
GO:0010727 IC negative regulation of hydrogen peroxide metabolic process
GO:0010870 IMP positive regulation of receptor biosynthetic process
GO:0016234 IDA inclusion body
GO:0016235 IDA aggresome
GO:0016236 IMP macroautophagy
GO:0016575 IDA histone deacetylation
GO:0019899 ISS enzyme binding
GO:0030286 IDA dynein complex
GO:0030424 ISS axon
GO:0030425 ISS dendrite
GO:0031252 IDA cell leading edge
GO:0031593 IDA polyubiquitin binding
GO:0032041 IEA NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032418 IMP lysosome localization
GO:0034983 IMP peptidyl-lysine deacetylation
GO:0035967 IMP cellular response to topologically incorrect protein
GO:0040029 IMP regulation of gene expression, epigenetic
GO:0042826 IPI histone deacetylase binding
GO:0042903 ISS tubulin deacetylase activity
GO:0043014 IDA alpha-tubulin binding
GO:0043130 IEA ubiquitin binding
GO:0043162 IEA ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043204 ISS perikaryon
GO:0043234 IEA protein complex
GO:0043241 IEA protein complex disassembly
GO:0043242 IMP negative regulation of protein complex disassembly
GO:0045598 IEA regulation of fat cell differentiation
GO:0045861 IMP negative regulation of proteolysis
GO:0045892 ISS negative regulation of transcription, DNA-templated
GO:0046969 IEA NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970 IEA NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048156 IDA tau protein binding
GO:0048471 IDA perinuclear region of cytoplasm
GO:0048487 IEA beta-tubulin binding
GO:0051354 IC negative regulation of oxidoreductase activity
GO:0051788 IMP response to misfolded protein
GO:0051879 IDA Hsp90 protein binding
GO:0060632 IC regulation of microtubule-based movement
GO:0060765 TAS regulation of androgen receptor signaling pathway
GO:0070201 IEA regulation of establishment of protein localization
GO:0070301 IMP cellular response to hydrogen peroxide
GO:0070840 IDA dynein complex binding
GO:0070842 IMP aggresome assembly
GO:0070845 IMP polyubiquitinated misfolded protein transport
GO:0070846 IMP Hsp90 deacetylation
GO:0070848 IMP response to growth factor
GO:0070932 IEA histone H3 deacetylation
GO:0070933 IEA histone H4 deacetylation
GO:0071218 IEA cellular response to misfolded protein
GO:0090035 IMP positive regulation of chaperone-mediated protein complex assembly
GO:0090042 ISS tubulin deacetylation
GO:0097372 IEA NAD-dependent histone deacetylase activity (H3-K18 specific)
GO:1901300 IDA positive regulation of hydrogen peroxide-mediated programmed cell death

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000115642 Hdac6-001 protein_coding Mus_musculus 0 2497
ENSMUST00000033501 Hdac6-201 protein_coding Mus_musculus 0 2495
ENSMUST00000145675 Hdac6-003 protein_coding Mus_musculus 0 2495
ENSMUST00000137499 Hdac6-002 retained_intron Mus_musculus 0 1277
ENSMUST00000133349 Hdac6-005 protein_coding Mus_musculus 0 556
ENSMUST00000154200 Hdac6-006 retained_intron Mus_musculus 0 453
ENSMUST00000156127 Hdac6-007 retained_intron Mus_musculus 0 228

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