ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: glutamate-cysteine ligase, catalytic subunit
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000514004 GCLC-003 ENSG00000001084 9606 - 6:53512989-53545033 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; HUVECENST00000514004
Transcript ID HUVEC
ENST00000514004 1.391±0.09

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000096 TAS sulfur amino acid metabolic process
GO:0000287 IDA magnesium ion binding
GO:0004357 IEA:IDA glutamate-cysteine ligase activity
GO:0005524 IEA ATP binding
GO:0005737 IBA cytoplasm
GO:0005829 TAS cytosol
GO:0006534 IDA cysteine metabolic process
GO:0006536 IDA glutamate metabolic process
GO:0006750 IEA glutathione biosynthetic process
GO:0006805 TAS xenobiotic metabolic process
GO:0006979 IDA response to oxidative stress
GO:0009408 IDA response to heat
GO:0009725 IDA response to hormone
GO:0016595 IDA glutamate binding
GO:0034641 TAS cellular nitrogen compound metabolic process
GO:0043066 IDA negative regulation of apoptotic process
GO:0043531 IDA ADP binding
GO:0044281 TAS small molecule metabolic process
GO:0045454 IDA cell redox homeostasis
GO:0045892 IDA negative regulation of transcription, DNA-templated
GO:0050662 IPI coenzyme binding
GO:0050880 IMP regulation of blood vessel size
GO:1901687 TAS glutathione derivative biosynthetic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000034905 Gclc-001 protein_coding Mus_musculus 0 904

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