ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: Rap guanine nucleotide exchange factor (GEF) 2
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000109756 RAPGEF2 9606 + 4:159104178-159360169 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000264431 RAPGEF2-001 159267737-159360169 protein_coding
  ENST00000502485 RAPGEF2-009 159343294-159346998 protein_coding
  ENST00000503328 RAPGEF2-005 159229337-159241363 processed_transcript
  ENST00000504604 RAPGEF2-004 159228254-159322363 processed_transcript
  ENST00000505026 RAPGEF2-011 159350228-159354045 protein_coding
  ENST00000505478 RAPGEF2-003 159104178-159314768 protein_coding
  ENST00000509891 RAPGEF2-012 159352457-159353569 retained_intron
  ENST00000510253 RAPGEF2-010 159345216-159353504 protein_coding
  ENST00000510510 RAPGEF2-008 159267161-159322449 protein_coding
  ENST00000511336 RAPGEF2-007 159266881-159323515 protein_coding
  ENST00000512056 RAPGEF2-013 159331626-159332856 protein_coding
  ENST00000513816 RAPGEF2-002 159326661-159330653 retained_intron
  ENST00000514565 RAPGEF2-006 159282504-159323470 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHUVECENST00000264431ENST00000505026ENST00000505478
Transcript ID BECs HAoEC HUVEC
ENST00000264431 0.221±0.00 8.384±0.14 7.502±4.09
ENST00000505026 N/A N/A 15.363±0.00
ENST00000505478 N/A N/A 21.949±0.00

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000165 NAS MAPK cascade
GO:0001568 ISS blood vessel development
GO:0001764 ISS neuron migration
GO:0004871 TAS signal transducer activity
GO:0005085 IEA guanyl-nucleotide exchange factor activity
GO:0005088 IDA Ras guanyl-nucleotide exchange factor activity
GO:0005509 NAS calcium ion binding
GO:0005515 IPI:IEA protein binding
GO:0005622 IEA intracellular
GO:0005737 IDA cytoplasm
GO:0005770 IDA late endosome
GO:0005886 ISS plasma membrane
GO:0005887 NAS integral component of plasma membrane
GO:0005911 ISS cell-cell junction
GO:0007165 IEA signal transduction
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007218 IDA neuropeptide signaling pathway
GO:0007264 TAS:IEA small GTPase mediated signal transduction
GO:0008285 IDA negative regulation of cell proliferation
GO:0010976 ISS positive regulation of neuron projection development
GO:0016020 IDA membrane
GO:0017034 IDA Rap guanyl-nucleotide exchange factor activity
GO:0019901 IEA protein kinase binding
GO:0019933 NAS cAMP-mediated signaling
GO:0019992 NAS diacylglycerol binding
GO:0021591 ISS ventricular system development
GO:0021884 ISS forebrain neuron development
GO:0030165 IDA PDZ domain binding
GO:0030552 IDA cAMP binding
GO:0031175 IDA neuron projection development
GO:0031547 ISS brain-derived neurotrophic factor receptor signaling pathway
GO:0031697 IDA beta-1 adrenergic receptor binding
GO:0032092 ISS positive regulation of protein binding
GO:0032320 IDA positive regulation of Ras GTPase activity
GO:0032486 IMP Rap protein signal transduction
GO:0032854 IDA positive regulation of Rap GTPase activity
GO:0035556 TAS intracellular signal transduction
GO:0038180 ISS nerve growth factor signaling pathway
GO:0043005 ISS neuron projection
GO:0043025 ISS neuronal cell body
GO:0043234 ISS protein complex
GO:0043950 IDA positive regulation of cAMP-mediated signaling
GO:0045202 ISS synapse
GO:0045860 IDA positive regulation of protein kinase activity
GO:0046582 IDA Rap GTPase activator activity
GO:0048022 ISS negative regulation of melanin biosynthetic process
GO:0048167 ISS regulation of synaptic plasticity
GO:0048471 IDA perinuclear region of cytoplasm
GO:0050699 IDA WW domain binding
GO:0050774 IDA negative regulation of dendrite morphogenesis
GO:0051056 IEA regulation of small GTPase mediated signal transduction
GO:0061028 IMP establishment of endothelial barrier
GO:0070374 IDA positive regulation of ERK1 and ERK2 cascade
GO:0071320 IDA cellular response to cAMP
GO:0071321 IDA cellular response to cGMP
GO:0071880 IDA adenylate cyclase-activating adrenergic receptor signaling pathway
GO:1901888 IMP regulation of cell junction assembly
GO:1990090 ISS cellular response to nerve growth factor stimulus
GO:2000481 IDA positive regulation of cAMP-dependent protein kinase activity
GO:2000670 IDA positive regulation of dendritic cell apoptotic process
GO:2001214 ISS positive regulation of vasculogenesis
GO:2001224 ISS positive regulation of neuron migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005482 rapgef2 protein_coding Danio_rerio
ENSDARG00000061459 si:dkey-253i9.4 protein_coding Danio_rerio
ENSMUSG00000062232 Rapgef2 protein_coding Mus_musculus

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