ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description:
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSMUSG00000062232 Rapgef2 10090 - 3:79062516-79286517 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENSMUST00000118100 Rapgef2-001 79062516-79144977 protein_coding
  ENSMUST00000118340 Rapgef2-002 79062528-79145875 protein_coding
  ENSMUST00000124647 Rapgef2-004 79112181-79173300 processed_transcript
  ENSMUST00000136126 Rapgef2-005 79169449-79181340 retained_intron
  ENSMUST00000152275 Rapgef2-003 79109066-79173198 retained_intron
  ENSMUST00000195708 Rapgef2-006 79062531-79286517 protein_coding

Expression Patterns


Heat Map
Numeric Values
Transcript'; C166Tie2+ ECmESENSMUST00000118100ENSMUST00000118340ENSMUST00000136126ENSMUST00000195708
Transcript ID C166 Tie2+ EC mES
ENSMUST00000118100 N/A 1.714±0.00 N/A
ENSMUST00000118340 N/A 3.249±1.42 N/A
ENSMUST00000136126 N/A 1.534±0.00 N/A
ENSMUST00000195708 3.271±0.86 5.127±2.29 1.324±1.02

Conserved Regions

Not located within a conserved region.

Gene Ontology
GO IDEvidence TypeGO Description
GO:0001568 IMP blood vessel development
GO:0001764 IMP neuron migration
GO:0005088 ISS Ras guanyl-nucleotide exchange factor activity
GO:0005096 IEA GTPase activator activity
GO:0005737 ISS cytoplasm
GO:0005770 ISS late endosome
GO:0005886 ISS plasma membrane
GO:0005911 ISS cell-cell junction
GO:0007186 IDA G-protein coupled receptor signaling pathway
GO:0007218 IDA neuropeptide signaling pathway
GO:0008285 IMP negative regulation of cell proliferation
GO:0010976 ISS positive regulation of neuron projection development
GO:0016020 ISS membrane
GO:0017034 ISS Rap guanyl-nucleotide exchange factor activity
GO:0019901 IEA protein kinase binding
GO:0019933 IDA cAMP-mediated signaling
GO:0021591 IMP ventricular system development
GO:0021884 IMP forebrain neuron development
GO:0030165 ISS PDZ domain binding
GO:0030552 ISS cAMP binding
GO:0031175 IMP neuron projection development
GO:0031547 ISS brain-derived neurotrophic factor receptor signaling pathway
GO:0031697 ISS beta-1 adrenergic receptor binding
GO:0032092 IDA positive regulation of protein binding
GO:0032320 ISS positive regulation of Ras GTPase activity
GO:0032486 ISS Rap protein signal transduction
GO:0032854 ISS positive regulation of Rap GTPase activity
GO:0038180 ISS nerve growth factor signaling pathway
GO:0043005 ISS neuron projection
GO:0043025 ISS neuronal cell body
GO:0043234 ISS protein complex
GO:0043950 ISS positive regulation of cAMP-mediated signaling
GO:0045202 ISS synapse
GO:0045860 ISS positive regulation of protein kinase activity
GO:0046582 IEA Rap GTPase activator activity
GO:0048022 IMP negative regulation of melanin biosynthetic process
GO:0048167 ISS regulation of synaptic plasticity
GO:0048471 ISS perinuclear region of cytoplasm
GO:0050699 ISS WW domain binding
GO:0050774 IMP negative regulation of dendrite morphogenesis
GO:0061028 ISS establishment of endothelial barrier
GO:0070374 IMP positive regulation of ERK1 and ERK2 cascade
GO:0071320 ISS cellular response to cAMP
GO:0071321 ISS cellular response to cGMP
GO:0071880 ISS adenylate cyclase-activating adrenergic receptor signaling pathway
GO:1901888 ISS regulation of cell junction assembly
GO:1990090 ISS cellular response to nerve growth factor stimulus
GO:2000481 IMP positive regulation of cAMP-dependent protein kinase activity
GO:2000670 IMP positive regulation of dendritic cell apoptotic process
GO:2001214 IMP positive regulation of vasculogenesis
GO:2001224 IMP positive regulation of neuron migration

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000005482 rapgef2 protein_coding Danio_rerio
ENSDARG00000061459 si:dkey-253i9.4 protein_coding Danio_rerio
ENSG00000109756 RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 protein_coding Homo_sapiens

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