ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Gene Info

Description: apoptotic peptidase activating factor 1
Gene AccessionGene NameTax IDStrandPositionGene Biotype
ENSG00000120868 APAF1 9606 + 12:98645141-98735433 protein_coding
  Transcript Accession Transcript Name Position Transcript Biotype
  ENST00000333991 APAF1-201 98645300-98735426 protein_coding
  ENST00000357310 APAF1-202 98645300-98735426 protein_coding
  ENST00000359972 APAF1-001 98645300-98735433 protein_coding
  ENST00000546491 APAF1-009 98699496-98712761 processed_transcript
  ENST00000547045 APAF1-005 98648355-98732687 protein_coding
  ENST00000547666 APAF1-008 98733648-98735418 processed_transcript
  ENST00000547743 APAF1-007 98645671-98648932 protein_coding
  ENST00000549007 APAF1-006 98648360-98732566 protein_coding
  ENST00000550527 APAF1-004 98648353-98735426 protein_coding
  ENST00000551964 APAF1-002 98645141-98733527 protein_coding
  ENST00000552268 APAF1-003 98648316-98732563 protein_coding
  ENST00000552929 APAF1-010 98723269-98733059 processed_transcript
  ENST00000555047 APAF1-011 98670861-98671697 retained_intron

Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHMVEC-DHUVECENST00000357310ENST00000547045ENST00000547666ENST00000549007ENST00000550527ENST00000551964
Transcript ID BECs HAoEC HHSEC HMVEC-D HUVEC
ENST00000357310 N/A 3.038±0.09 N/A N/A 0.761±0.54
ENST00000547045 N/A 2.142±0.46 N/A 1.920±0.00 1.614±0.73
ENST00000547666 N/A N/A 1.669±0.00 N/A N/A
ENST00000549007 N/A 1.972±0.19 N/A N/A N/A
ENST00000550527 0.415±0.00 N/A 0.290±0.00 N/A 1.032±0.79
ENST00000551964 N/A 6.105±0.44 N/A N/A 2.064±1.19

Conserved Regions

Region IDSub-RegionRegion Type
CIL_00090D CIL_00090D_0001 VISTA
CIL_0000T8 CIL_0000T8_0002 CGP

Gene Ontology
GO IDEvidence TypeGO Description
GO:0000166 TAS nucleotide binding
GO:0001843 IEA neural tube closure
GO:0005515 IPI protein binding
GO:0005524 IEA ATP binding
GO:0005634 IEA nucleus
GO:0005829 TAS cytosol
GO:0006915 TAS apoptotic process
GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007275 IEA multicellular organismal development
GO:0007399 TAS nervous system development
GO:0007420 IEA brain development
GO:0008635 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008656 NAS cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0030900 IEA forebrain development
GO:0042802 IEA identical protein binding
GO:0042981 TAS:IEA regulation of apoptotic process
GO:0043065 TAS positive regulation of apoptotic process
GO:0043293 TAS apoptosome
GO:0043531 IEA ADP binding
GO:0051402 IEA neuron apoptotic process
GO:0070062 IDA extracellular vesicular exosome
GO:0072432 TAS response to G1 DNA damage checkpoint signaling
GO:0097190 IEA apoptotic signaling pathway
GO:0097193 TAS intrinsic apoptotic signaling pathway
GO:1902510 IEA regulation of apoptotic DNA fragmentation
GO:2001235 IEA positive regulation of apoptotic signaling pathway

Homologs

ENSEMBL Accession Gene Name Description Biotype Species
ENSDARG00000021239 apaf1 protein_coding Danio_rerio
ENSMUSG00000019979 Apaf1 protein_coding Mus_musculus

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