ANGIOGENES: A knowledge database for angiogenesis

Institute of Cardiovascular Regeneration, Goethe University Frankfurt

Transcript Info
Description: SRY (sex determining region Y)-box 9
Transcript Accession Transcript Name Contained in Gene Tax ID Strand Position Biotype
ENST00000245479 SOX9-001 ENSG00000125398 9606 + 17:72121020-72126420 protein_coding

Homo sapiens Ensembl GRCh38

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Expression Patterns


Heat Map
Numeric Values
Transcript'; BECsHAoECHHSECHUVECENST00000245479
Transcript ID BECs HAoEC HHSEC HUVEC
ENST00000245479 0.054±0.00 0.123±0.06 0.194±0.00 0.037±0.05

Conserved Regions

Not located within a conserved region.

Gene Ontology

GO IDEvidence TypeGO Description
GO:0000976 IEA transcription regulatory region sequence-specific DNA binding
GO:0000981 IEA sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001046 IDA core promoter sequence-specific DNA binding
GO:0001077 IDA RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001158 ISS enhancer sequence-specific DNA binding
GO:0001501 IMP skeletal system development
GO:0001502 ISS cartilage condensation
GO:0001503 IEA ossification
GO:0001658 IEA branching involved in ureteric bud morphogenesis
GO:0001708 ISS cell fate specification
GO:0001837 ISS epithelial to mesenchymal transition
GO:0001894 ISS tissue homeostasis
GO:0001934 ISS positive regulation of protein phosphorylation
GO:0001942 ISS hair follicle development
GO:0002053 ISS positive regulation of mesenchymal cell proliferation
GO:0002062 IEA chondrocyte differentiation
GO:0002063 IEA chondrocyte development
GO:0002683 ISS negative regulation of immune system process
GO:0003170 ISS heart valve development
GO:0003179 ISS heart valve morphogenesis
GO:0003188 IEA heart valve formation
GO:0003203 ISS endocardial cushion morphogenesis
GO:0003413 IMP chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0003415 ISS chondrocyte hypertrophy
GO:0003677 IEA DNA binding
GO:0003682 IDA chromatin binding
GO:0003700 IDA sequence-specific DNA binding transcription factor activity
GO:0003705 IDA RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004672 ISS protein kinase activity
GO:0005515 IPI protein binding
GO:0005634 IDA nucleus
GO:0005667 IEA transcription factor complex
GO:0006334 IDA nucleosome assembly
GO:0006338 IDA chromatin remodeling
GO:0006357 IEA regulation of transcription from RNA polymerase II promoter
GO:0006366 IEA transcription from RNA polymerase II promoter
GO:0006461 IDA protein complex assembly
GO:0006468 IEA protein phosphorylation
GO:0007010 IEA cytoskeleton organization
GO:0007165 ISS signal transduction
GO:0007173 ISS epidermal growth factor receptor signaling pathway
GO:0007283 ISS spermatogenesis
GO:0007417 IEA central nervous system development
GO:0007507 IEA heart development
GO:0008013 IEA beta-catenin binding
GO:0008284 IMP positive regulation of cell proliferation
GO:0008285 IEA negative regulation of cell proliferation
GO:0008584 IEP male gonad development
GO:0010564 IMP regulation of cell cycle process
GO:0010628 IEA positive regulation of gene expression
GO:0010634 IMP positive regulation of epithelial cell migration
GO:0014032 IEA neural crest cell development
GO:0014068 ISS positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016337 IEA single organismal cell-cell adhesion
GO:0019100 ISS male germ-line sex determination
GO:0019933 IDA cAMP-mediated signaling
GO:0030154 IEA cell differentiation
GO:0030155 IEA regulation of cell adhesion
GO:0030198 IEA extracellular matrix organization
GO:0030238 IEA male sex determination
GO:0030279 ISS negative regulation of ossification
GO:0030502 IEA negative regulation of bone mineralization
GO:0030850 IEP prostate gland development
GO:0030857 IEA negative regulation of epithelial cell differentiation
GO:0030858 ISS positive regulation of epithelial cell differentiation
GO:0030879 IEA mammary gland development
GO:0030903 IEA notochord development
GO:0030916 ISS otic vesicle formation
GO:0031018 IEA endocrine pancreas development
GO:0032331 ISS negative regulation of chondrocyte differentiation
GO:0032332 IMP positive regulation of chondrocyte differentiation
GO:0034236 IPI protein kinase A catalytic subunit binding
GO:0035019 ISS somatic stem cell maintenance
GO:0035326 IDA enhancer binding
GO:0035622 IEA intrahepatic bile duct development
GO:0042127 ISS regulation of cell proliferation
GO:0042981 ISS regulation of apoptotic process
GO:0043066 ISS negative regulation of apoptotic process
GO:0043234 IDA protein complex
GO:0043425 IEA bHLH transcription factor binding
GO:0043491 IEA protein kinase B signaling
GO:0043565 IEA sequence-specific DNA binding
GO:0044212 IEA transcription regulatory region DNA binding
GO:0044798 IEA nuclear transcription factor complex
GO:0045165 IEA cell fate commitment
GO:0045595 IEA regulation of cell differentiation
GO:0045662 ISS negative regulation of myoblast differentiation
GO:0045732 IEA positive regulation of protein catabolic process
GO:0045892 IMP negative regulation of transcription, DNA-templated
GO:0045893 IDA positive regulation of transcription, DNA-templated
GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter
GO:0046533 ISS negative regulation of photoreceptor cell differentiation
GO:0046982 IEA protein heterodimerization activity
GO:0048709 IEA oligodendrocyte differentiation
GO:0050679 ISS positive regulation of epithelial cell proliferation
GO:0050680 ISS negative regulation of epithelial cell proliferation
GO:0051216 ISS cartilage development
GO:0060008 ISS Sertoli cell differentiation
GO:0060009 IEA Sertoli cell development
GO:0060018 IEA astrocyte fate commitment
GO:0060041 ISS retina development in camera-type eye
GO:0060174 IEA limb bud formation
GO:0060221 ISS retinal rod cell differentiation
GO:0060350 IEA endochondral bone morphogenesis
GO:0060441 IEA epithelial tube branching involved in lung morphogenesis
GO:0060487 IEA lung epithelial cell differentiation
GO:0060512 IEA prostate gland morphogenesis
GO:0060517 ISS epithelial cell proliferation involved in prostatic bud elongation
GO:0060729 ISS intestinal epithelial structure maintenance
GO:0060784 ISS regulation of cell proliferation involved in tissue homeostasis
GO:0061036 IDA positive regulation of cartilage development
GO:0061046 IEA regulation of branching involved in lung morphogenesis
GO:0061138 ISS morphogenesis of a branching epithelium
GO:0070168 ISS negative regulation of biomineral tissue development
GO:0070371 ISS ERK1 and ERK2 cascade
GO:0071260 ISS cellular response to mechanical stimulus
GO:0071300 IEP cellular response to retinoic acid
GO:0071347 IEP cellular response to interleukin-1
GO:0071364 ISS cellular response to epidermal growth factor stimulus
GO:0071504 ISS cellular response to heparin
GO:0071560 IDA cellular response to transforming growth factor beta stimulus
GO:0071599 IEA otic vesicle development
GO:0072034 ISS renal vesicle induction
GO:0072170 IEA metanephric tubule development
GO:0072189 IEA ureter development
GO:0072190 IEA ureter urothelium development
GO:0072193 IEA ureter smooth muscle cell differentiation
GO:0072197 IEA ureter morphogenesis
GO:0072289 ISS metanephric nephron tubule formation
GO:0090090 ISS negative regulation of canonical Wnt signaling pathway
GO:0090103 ISS cochlea morphogenesis
GO:0090184 ISS positive regulation of kidney development
GO:0090190 ISS positive regulation of branching involved in ureteric bud morphogenesis
GO:0097157 IEA pre-mRNA intronic binding
GO:1901203 IEA positive regulation of extracellular matrix assembly
GO:2000020 IDA positive regulation of male gonad development
GO:2000138 IEA positive regulation of cell proliferation involved in heart morphogenesis
GO:2000741 IDA positive regulation of mesenchymal stem cell differentiation
GO:2000794 IEA regulation of epithelial cell proliferation involved in lung morphogenesis
GO:2001054 IEA negative regulation of mesenchymal cell apoptotic process

Homologs

ENSEMBL Accession Gene Name Biotype Species E-Value Bit Score
ENSMUST00000000579 Sox9-001 protein_coding Mus_musculus 0 2290
ENSDART00000005676 sox9a-001 protein_coding Danio_rerio 0 647
ENSDART00000127937 sox9a-201 protein_coding Danio_rerio 0 571
ENSMUST00000040019 Sox10-201 protein_coding Mus_musculus 0 420
ENSMUST00000054491 Sox18-001 protein_coding Mus_musculus 2e-25 122
ENSMUST00000170662 Sox21-001 protein_coding Mus_musculus 7e-25 121
ENSMUST00000180353 Sox1-001 protein_coding Mus_musculus 7e-20 104
ENSMUST00000047373 Sox15-001 protein_coding Mus_musculus 0.00000000002 77

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